Immunohistochemical and Molecular Analyses Focusing on Mesenchymal Cells in Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis

Conclusion: This study suggests the significance of theBRAFV600E mutation and activation of Wnt signaling pathway in the carcinoma cells and DTF components, respectively. We believe that theCTNNB1 mutations are not the major factor behind β-catenin translocation indicating Wnt pathway activation. Further study is required to evaluate whether molecular abnormalities other than theCTNNB1 mutation cause activation of Wnt signaling in DTF components of PTC-DTF.Pathobiology
Source: Pathobiology - Category: Pathology Source Type: research