Parallels between Mammalian Mechanisms of Monoallelic Gene Expression.

Parallels between Mammalian Mechanisms of Monoallelic Gene Expression.
Trends Genet. 2018 Sep 11;:
Authors: Khamlichi AA, Feil R
Abstract
Different types of monoallelic gene expression are present in mammals, some of which are highly flexible, whereas others are more rigid. These include allelic exclusion at antigen receptor loci, the expression of olfactory receptor genes, genomic imprinting, X-chromosome inactivation, and random monoallelic expression (MAE). Although these processes play diverse biological roles, and arose through different selective pressures, the underlying epigenetic mechanisms show striking resemblances. Regulatory transcriptional events are important in all systems, particularly in the specification of MAE. Combined with comparative studies between species, this suggests that the different MAE systems found in mammals may have evolved from analogous ancestral processes.
PMID: 30217559 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - September 11, 2018 Category: Genetics & Stem Cells Authors: Khamlichi AA, Feil R Tags: Trends Genet Source Type: research