Is magnetic resonance diffusion-weighted imaging superior in the diagnosis of pancreatic adenocarcinoma and does it have a prognostic value?

Publication date: Available online 15 September 2018Source: The Egyptian Journal of Radiology and Nuclear MedicineAuthor(s): Amr F. Mourad, Mona M. Sayed, Hussein FakhryAbstractAimTo assess how beneficial is adding Magnetic Resonance Diffusion-Weighted Imaging (DWI) to conventional MRI in the identification, characterization, and prognostic assessment of pancreatic duct adenocarcinoma (PDAC).Materials and MethodsWe included 34 consecutive patients with pancreatic malignancies who had conventional MRI and DWI performed and were followed up after treatment.ResultsThe apparent diffusion coefficient (ADC) values of malignant pancreatic mass lesions ranged from 0.9 to 1.5 × 10−3s/mm2 at b-1000, with a mean of 1.2 ± 0.18093. For the surrounding parenchyma, the ADC values were from 1.8 to 2.9 × 10−3s/mm2 at b-1000, with a mean of 2.3 ± 0.35506. These values showed a statistically significant difference (P 
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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ConclusionMDSC analysis aids in defining the immune landscape of PDAC patients for a more appropriate diagnosis, stratification and treatment.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Conclusions The deep learning protocol showed accuracy comparable to current radiographic criteria. Computer-aided frameworks could be implemented as aids for radiologists to identify high-risk IPMN.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractA promising approach capitalizing on the specific and highly sensitive characteristics of the body ’s own immune system is demonstrated in the context of revealing pancreatic ductal adenocarcinoma cancer (PDAC). IgA from a local biofluid called gastrointestinal lavage fluid (GLF) is used to investigate glycan reactivity to show the potential of this approach. IgA antibody responses, just as wit h IgG, result in amplification of a small signal which aids in detecting changes from a healthy state. IgA from GLF was screened against glycan arrays containing 609 glycan structures to investigate differential bindin...
Source: Glycoconjugate Journal - Category: Biochemistry Source Type: research
Objectives Pancreatic ductal adenocarcinoma (PDAC) is associated with increased coagulation and venous thrombotic events (VTE). PDAC is often diagnosed late and survival is poor. CA 19-9 is the most used tumor marker for PDAC, but it is more useful in follow-up than diagnosis. Intraductal papillary mucinous neoplasm (IPMN) is a benign tumor of the pancreas, which can become malignant, however pancreatic tumor surgery is extensive and should not be done needlessly. The aim of this study was to study whether PDAC could be distinguished from IPMN preoperatively using coagulation biomarkers and whether combing them in a panel ...
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 8. Pancreatic Cancer I Source Type: research
AbstractInsulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysin (SYP), and neural cell adhesion molecule (NCAM) were also considered as potential biomarkers. However, it is often difficult to diagnose it immunohistochemically. Hence, we examined the expression pattern of INSM1 in pancreatic solid tumors. We detected INSM1, CGA, SYP, and NCAM immunohistochemically, in 27 cases of NET [pure type: 25 cases, mixed adenoneuroendocrine carcinoma (MANEC): 2 cases]. We included ...
Source: Medical Molecular Morphology - Category: Molecular Biology Source Type: research
Conclusion Surveillance of CDNK2A mutation carriers is relatively successful, detecting most PDACs at a resectable stage. The benefit of surveillance in families with FPC is less evident.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Prognostic Studies, Population and observational studies (SEER, WHI observational, etc.) Cancer Prevention and Control Source Type: research
Authors: Bhutani M, Koduru P, Lanke G, Bruno M, Maitra A, Giovannini M Abstract Pancreatic ductal adenocarcinoma is a lethal cancer with a 5-year survival rate of less than 5%. Surgical resection is the only curative treatment but only 20% are eligible for resection at the time of diagnosis. Early detection of cancer is of paramount importance in the management. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the preferred modality for obtaining tissue diagnosis of pancreatic masses. However, the diagnostic accuracy of EUS-FNA may be limited by several factors like availability of onsite cytopathol...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Next generation sequencing (NGS) technologies are rapidly being incorporated into the clinic to facilitate decisions on cancer patient care. However, successful translation of NGS data requires knowledge on which DNA aberrations represent actionable events, either for development or re-positioning of approved agents to target their activated pathways. Recognizing this, large-scale tumor profiling efforts by consortia such as The Cancer Genome Atlas (TCGA) are cataloging genomic aberrations across major cancer lineages. These efforts have revealed an extraordinary level of genome complexity made up of not only key “dr...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Genomics and Target Discovery Source Type: research
In this study, we used a laser microdissection approach of human PDAC stromal and epithelial compartment, followed by mass spectrometry and bioinformatics analysis (statistics/interactome) to compare protein composition and networks within both compartments. We found the presence of a proteic complex composed of three proteins, expressed only in stromal compartment, related to lipid and intracellular trafficking. To validate such data, we confirmed the specific stromal expression of each protein, on human PDAC samples, and found that our three targets were expressed mainly in stellate cells. However before to investigate t...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Inflammation/Stroma Source Type: research
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