The novel early use of dexmedetomidine in the management of tetanus

Tetanus is a neurotoxin-mediated disease characterized by muscle spasms, rigidity, airway compromise, and sympathetic overactivity. The incidence of tetanus in developed countries has fallen significantly with the implementation of the tetanus vaccine, with only 233 cases reported in the United States from 2001 to 2008. Due to the decreasing incidence, many providers in developed countries lack experience in the management of tetanus. Autonomic dysfunction, which manifests as intermittent labile tachycardia, hypertension and arrhythmias often followed by periods of hypotension and bradycardia, is a major cause of morbidity and mortality [1].
Source: Journal of Clinical Anesthesia - Category: Anesthesiology Authors: Tags: Correspondence Source Type: research