Shared co-expression networks in frontal cortex of the normal aged brain and schizophrenia

Previous studies on the brain of people with schizophrenia have identified structural changes and gene expression changes, suggesting that brain aging maybe accelerated in people with schizophrenia. To better characterize gene expression profiles in schizophrenia and in the aged population we constructed co-expression networks using RNA-Seq data from frontal cortex. The first data set analysed was from 62 subjects with schizophrenia and 51 unaffected controls ranging in age from 19 to 63  years. The second separate data set was from normal control individuals ranging in age from 29 to 106 years.
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research