Progression of myocardial ischemia leads to unique changes in immediate early gene expression in the spinal cord dorsal horn.

Progression of myocardial ischemia leads to unique changes in immediate early gene expression in the spinal cord dorsal horn. Am J Physiol Heart Circ Physiol. 2018 Sep 14;: Authors: Saddic LA, Howard-Quijano K, Kipke J, Kubo Y, Dale EA, Hoover DB, Shivkumar K, Eghbali M, Mahajan A Abstract The pathological consequences of ischemic heart disease involve signaling through the autonomic nervous system (ANS). While early activation may serve to maintain hemodynamic stability, persistent aberrant sympatho-excitation contributes to the development of lethal arrhythmias and heart failure. We hypothesize that as myocardium reacts and remodels to ischemic injury over time, there is an analogous sequence of gene expression changes in the thoracic spinal cord dorsal horn, the processing center for incoming afferent fibers from the heart to the central nervous system. Acute and chronic myocardial ischemia (MI) was induced in a large animal model of Yorkshire pigs and the thoracic dorsal horn of treated animals, along with control non-ischemic pigs, was harvested for transcriptome analysis. We identified 32 differentially expressed genes between healthy and acute ischemia cohorts and 46 differentially expressed genes between healthy and chronic ischemia cohorts. The canonical immediate early gene (IEG) c-fos was up-regulated following acute MI along with fosB, dusp1, dusp2, and egr2. Following chronic MI, there was a persistent yet unique activat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research