Association of IL4R-rs1805016 and IL6R-rs8192284 polymorphisms with clinical dengue in children from Colombian populations

Etiologic studies provide evidence that IL-4R and IL-6R receptors may play important roles in the regulatory mechanisms of the development of clinical dengue, especially in children which is a segment of the population with high severe dengue risk. Moreover, the allele frequencies and genetic associations may be influenced by the populational genetic background. Therefore, we performed a case-control study to evaluate possible associations between SNPs in IL4R and IL6R genes and clinical dengue in children from two Colombian populations.

Source: Journal of Infection and Public Health - September 15, 2018 Category: International Medicine & Public Health Authors: Yerly M. Useche, Berta N. Restrepo, Doris M. Salgado, Carlos F. Narv áez, Omer Campo, Gabriel Bedoya Source Type: research