The impact of radiation therapy on lymphocyte count and survival in metastatic cancer patients receiving PD-1 immune checkpoint inhibitors

The impact of radiation therapy on circulating lymphocyte count and survival in metastatic cancer patients receiving immune checkpoint inhibitors (ICI) is unknown. In this retrospective review of 110 patients with metastatic NSCLC, melanoma, or RCC who received RT and PD-1 inhibitors, patients treated with>5 fractions of extracranial RT were more likely to experience severe lymphopenia (

Source: International Journal of Radiation Oncology * Biology * Physics - September 15, 2018 Category: Radiology Authors: Luke R.G. Pike, Andrew Bang, Brandon A. Mahal, Allison Taylor, Monica Krishnan, Alexander Spektor, Daniel N. Cagney, Ayal A. Aizer, Brian M. Alexander, Osama Rahma, Tracy Balboni, Patrick A. Ott, F. Stephen Hodi, Jonathan D. Schoenfeld Tags: Clinical Investigation Source Type: research