Excessive release of endogenous neuropeptide Y into cerebrospinal fluid after treatment of spontaneous subarachnoid haemorrhage and its possible impact on self-reported neuropsychological performance - results of a prospective clinical pilot study on good-grade patients.
DISCUSSION: To the best of our knowledge, this study is the first to correlate the levels of endogenous NPY in supratentorial CSF with cognitive outcome in good-grade sSAH patients. Excessive NPY release into CSF may have a short-term influence on the pathogenesis of neuropsychological deficits. The impact of cerebrovascular manipulation on NPY release has to be further elucidated. ABBREVIATIONS: ANOVA: analysis of variance; aSAH: aneurysmal subarachnoid haemorrhage; AUC: area under the curve; CBF: cerebral blood flow; CSF: cerebrospinal fluid; CT (scan): computed tomography (scan); CV: cerebral vasospasm; DIND: delayed ischemic neurological deficit; DSA: digital subtraction angiography; EIA: enzyme immunoassay; EV: endovascular aneurysm occlusion; EVD: external ventricular drainage; FU: 6-month follow-up; GCS: Glasgow Coma Scale; Ghp: general health perceptions; GOS: Glasgow Outcome Scale; h: hour/s; HH: Hunt and Hess; ICU: intensive care unit; ISR: ICD-10-Symptom-Rating questionnaire; MCS: mental component summary; Mhi: general mental health; min: minute/s; min-max: minimum - maximum; ml: millilitre; mRS: modified Ranking Scale; MS: microsurgical clipping, microsurgical aneurysm occlusion; ng: nanograms; no. [n]: number; NPY: Neuropeptide Y; p: p value; Pain: bodily pain; PCS: physical component summary; Pfi: physical functioning; pSAH: perimesencephalic subarachnoid haemorrhage; PTSD: posttraumatic stress disorder; QoL: quality of life; Rawhtran: health transition item...
Just wanted to give a shout out to the members of the anesthesia and pain management team at Cook County. Completed a rotation with them last month (August) and it was by far the best rotation experience I've had to date. The hands on experience and one-on-one with the residents had me feeling like I was a part of the team and actually useful (a feeling most of us can probably agree we don't often have as a medical student). Hours were good, team was great, and the experience overall was... Cook County Anesthesia elective
Publication date: Available online 17 September 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Yacine Carlier, Hubert Lenoir, Dominique M. Rouleau, Pierre Mansat, Anne Vidil, Matthieu Ferrand, Rémy Bleton, Olivier Herrisson, Vincent Salabi, Fabrice Duparc, François Kelberine, Pierre Desmoineaux, The French Arthroscopy Society (SFA)AbstractIntroductionOsteoarthritis is the second most frequent cause of elbow stiffness, after trauma sequelae. Surgical treatment mainly consists of debridement. The main aim of the present study was to assess the efficacy of arthroscopic treatment of o...
ConclusionsIntrauterine Bigatti Shaver® is a feasible technique for placental remnants removal. Further studies comparing various surgical treatment are needed to define which technique is the safest and completely remove placental remnants.
ConclusionsThis study shows that a relapse is accompanied by an increase in MS-related fatigue. Moreover, autonomic dysfunctions and introversion, more than depression and apathy, play a major role in the explanation of MS-related fatigue. This finding represents additional evidence for the relationship between inflammation, vagal afferent signalling, autonomic dysfunctions, introversion and the feeling of MS-related fatigue.KeywordsMultiple Sclerosis, fatigue, relapse, autonomic dysfunctions, vagal afferents
Publication date: December 2019Source: Research in Autism Spectrum Disorders, Volume 68Author(s): A. Muskett, N.N. Capriola-Hall, S. Ryan Radtke, R. Factor, A. ScarpaAbstractYouth with Autism Spectrum Disorder (ASD) experience depression and anxiety at higher rates than typically developing (TD) youth. The current study examined how restricted and repetitive behaviors or interests (RRBs) may be related to symptoms of depression and anxiety. Participants included 35 children with ASD (29 male, 6 female) between 3 and 14 years. Youth who met clinical cut-off for depression and anxiety demonstrated increased self-injurious be...
"As they become adults, we see continued anxiety, continued depression, real PTSD"
Infants and toddlers should not be given soda, chocolate milk or other sweetened drinks, according to strict new guidelines.