Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano.

Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano. Curr Gene Ther. 2018 Sep 13;: Authors: Venugopal C, Shobha K, Rai KS, Pinnelli VB, Kutty BM, Dhanushkodi A Abstract Mesenchymal stem cell (MSC) therapy in recent years have gained significant attention. Though the functional outcomes following MSC therapy for neurodegenerative diseases are convincing, various mechanisms for the functional recovery are being debated. Nevertheless, recent studies convincingly demonstrated that recovery following MSC therapy could be reiterated with MSC secretome per se thereby shifting the dogma from cell therapy to cell "based" therapy. In addition to various functional proteins, stem cell secretome also includes extracellular membrane vesicles like exosomes. Exosomes which are of "Nano" size have attracted significant interest as it can pass through the blood brain barrier far easily then macro size cells or growth factors. Exosomes act as a cargo between cells to bring about significant alterations in target cells. As the importance of exosomes are getting unwind, it is imperial to carry out a comprehensive study to evaluate the neuroprotective potential of exosomes as compared to conventional co-culture or total condition medium treatments. Thus, the present study is designed to compare the neuroprotective potential of MSC derived exosomes with MSC-condition medium or neuron-MSC-co-culture system against kainic acid...
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research