Treatment of Ciprofloxacin-resistant Ear Infections

This study investigates ciprofloxacin-resistant infections and seeks to develop a better understanding of treatment options and outcomes. Study Design: Retrospective review of 141 ciprofloxacin-resistant otologic infections. Setting: Tertiary-care hospital. Patients: Patients with culture-proven ciprofloxacin-resistant infections from 2008 to 2017. Intervention(s): Antibiotic treatment with ciprofloxacin topical drops, ciprofloxacin plus oral antibiotics, and nonciprofloxacin therapy. Main Outcome Measure(s): Bacteriology for ciprofloxacin-resistant infections and treatment effectiveness of various therapies. Results: Methicillin-resistant Staphylococcus aureus (33%), Corynebacterium striatum (19%), and non-Methicillin-resistant Staphylococcus aureus (11%) are the most frequent causes of ciprofloxacin-resistant infections. Topical ciprofloxacin monotherapy was successful in 2.7% of infections compared with a 64.7% success rate with the addition of an oral antibiotic (p 
Source: Otology and Neurotology - Category: ENT & OMF Tags: Middle Ear and Mastoid Disease Source Type: research