Intralipid Improves Oxygenation after Orthotopic Lung Transplantation

Intralipid (ILP), a clinically used lipid emulsion, protects from cardiac ischemia reperfusion (I/R) injury by inhibiting opening of the mitochondrial permeability transition pore.1 This reduces reactive oxygen species (ROS) production.2 We hypothesized that ILP would also attenuate pulmonary I/R injury. Here we examine the effect of ILP on mediators of tissue damage in a rat pulmonary I/R model and on clinically relevant outcomes in a rat orthotopic lung transplantation model.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research