LSTM led partnership awarded £ 1.5 million for NTD drug development

(Liverpool School of Tropical Medicine) An LSTM led partnership has been awarded nearly £ 1.5 million from the Medical Research Council (MRC) for the pre-clinical development of a candidate drug to treat onchocerciasis and lymphatic filariasis, by targeting the bacterial symbiont Wolbachia.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin A, was identified as a hit against Wolbachia. This bacterial endosymbiont is required for filarial worm viability and fertility and is a validated target for macrofilaricidal drugs. Medicinal chemistry was undertaken to develop tylosin A analogs with improved oral bioavailability. Two analogs, A-1535469 and A-1574083, were selected. Their efficacy was tested against the gold-s...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
by Thomas W. von Geldern, Howard E. Morton, Rick F. Clark, Brian S. Brown, Kelly L. Johnston, Louise Ford, Sabine Specht, Robert A. Carr, Deanne F. Stolarik, Junli Ma, Matthew J. Rieser, Dominique Struever, Stefan J. Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D. Turner, Marc P. H übner, Achim Hoerauf, Mark J. Taylor, Stephen A. Ward, Kennan Marsh, Dale J. Kempf There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substan...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01854
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Conclusions/SignificanceThe SD Bioline Onchocerciasis/LF IgG4 Rapid test appears to be a good tool for integrated exposure measures of LF and onchocerciasis in co-endemic areas.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the lack of a safe drug that can kill the adult filaria (macrofilaricide). Previous proof-of-concept human trials have...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
by Chelsea Fischer, Iosune Ibiricu Urriza, Christina A. Bulman, KC Lim, Jiri Gut, Sophie Lachau-Durand, Marc Engelen, Ludo Quirynen, Fetene Tekle, Benny Baeten, Brenda Beerntsen, Sara Lustigman, Judy Sakanari River blindness and lymphatic filariasis are two filarial diseases that globally affect millions of people mostly in impoverished countries. Current mass drug administration programs rely on drugs that primarily target the microfilariae, which are released from adult female worms. The female worms can live for several years, releasing millions of microfilariae throughout the course of infection. Thus, to stop transmi...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Onchocerciasis, or river blindness, is a dermal filariasis caused by infection with the nematode parasite Onchocerca volvulus, transmitted to humans through the bites of blackflies of the genus Simulium. Despite ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Conclusion: No environmental factors related with onchocerciasis were found, including proximity to rivers. This could be partially explained by the fact that the vector was eliminated in 2005.
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
by Arathi Arakala, Christopher M. Hoover, John M. Marshall, Susanne H. Sokolow, Giulio A. De Leo, Jason R. Rohr, Justin V. Remais, Manoj Gambhir Progress towards controlling and eliminating parasitic worms, including schistosomiasis, onchocerciasis, and lymphatic filariasis, is advancing rapidly as national governments, multinational NGOs, and pharmaceutical companies launch collaborative chemotherapeutic control campaigns. Critical questi ons remain regarding the potential for achieving elimination of these infections, and analytical methods can help to quickly estimate progress towards—and the probability of achie...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ConclusionsExtensive data collected over many years document the very significant impact of interventions conducted by the National Onchocerciasis and other Eyes Diseases Control Programme during challenging times with periods of civil unrest. The Health Ministry has now integrated efforts to control neglected tropical diseases and adopted the goal of onchocerciasis elimination.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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