LSTM led partnership awarded £ 1.5 million for NTD drug development

(Liverpool School of Tropical Medicine) An LSTM led partnership has been awarded nearly £ 1.5 million from the Medical Research Council (MRC) for the pre-clinical development of a candidate drug to treat onchocerciasis and lymphatic filariasis, by targeting the bacterial symbiont Wolbachia.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

Related Links:

In this study we tested oxfendazole, an anthelmintic shown to be well tolerated in phase 1 clinical trial s.In vitro, oxfendazole exhibited modest to marginal motility inhibition of adult worms ofOnchocerca gutturosa, pre-adult worms ofOnchocerca volvulus andOnchocerca lienalis microfilariae.In vivo, five days of oral treatments provided sterile cure with up to 100% macrofilaricidal efficacy in the murineLitomosoides sigmodontis model of filariasis. In addition, 10 days of oral treatments with oxfendazole inhibited filarial embryogenesis in patentL.sigmodontis-infected jirds and subsequently led to a protracted but complet...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Answer toParasite Case of the Week 580:Loa loamicrofilariae. As noted by several readers, the nuclei go to the tip of the tail, the microfilariae are relatively large, and there is faint evidence of a sheath, all of which are characteristic features for this species. As I teach my students, the nuclei " flow-a flow-a " (to the tip) in Loa loa. Another memory trick from William Sears is that the nuclei go " lower and lower " in Loa loa. Take your pick for your favorite! Remember that the sheath will not always be seen. Size is a more definitive feature in differentiating Mansonella spp. from th...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Abstract Plateau and Nasarawa states in central Nigeria were endemic for onchocerciasis. The rural populations of these two states received annual ivermectin mass drug administration (MDA) for a period of 8-26 years (1992-2017). Ivermectin combined with albendazole was given for 8-13 of these years for lymphatic filariasis (LF); the LF MDA program successfully concluded in 2012, but ivermectin MDA continued in areas known to have a baseline meso-/hyperendemic onchocerciasis. In 2017, serological and entomological assessments were undertaken to determine if MDA for onchocerciasis could be stopped in accordance with...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
The genus Onchocerca Diesing, 1841 includes species of medical importance, such as O. volvulus (Leuckart, 1893), which causes river blindness in the tropics. Recently, zoonotic onchocercosis has been reported in ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
by Alexandra Ehrens, Christopher S. Lunde, Robert T. Jacobs, Dominique Struever, Marianne Koschel, Stefan J. Frohberger, Franziska Lenz, Martina Fendler, Joseph D. Turner, Stephen A. Ward, Mark J. Taylor, Yvonne R. Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J. Plattner, Achim Hoerauf, Marc P. H übner The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal–adult worm killing–drug. In the present study, we tested thein vivo efficacy of AN11251, a boron-pleuromutilin that targets endosymbioticWolbachia bacteria from fil...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Onchocerciasis and lymphatic filariasis are targeted for elimination, primarily using mass drug administration at the country and community levels. Elimination of transmission is the onchocerciasis target and global elimination as a public health problem is the end point for lymphatic filariasis. Where program duration, treatment coverage, and compliance are sufficiently high, elimination is achievable for both parasites within defined geographic areas. However, transmission has re-emerged after apparent elimination in some areas, and in others has continued despite years of mass drug treatment. A critical question is whet...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Abstract Ivermectin is a widely used drug for the treatment of various neglected tropical diseases, such as lymphatic filariasis, onchocerciasis, and strongyloidiasis among others. Despite its excellent safety profile, there are few published studies of the use of ivermectin in children, pregnant and nursing women. In the present study, we report clinical data on ivermectin concentrations in breastmilk of a woman with Strongyloides stercoralis and HTLV-I coinfection. Ivermectin levels in breastmilk ranged from 1.4 to 20.8 ng/ml, with a mean of 9.26 ng/ml after a single dose of 200 µg/kg. We estimated the pos...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
[WHO] The Angolan Ministry of Health, with technical support from WHO, carried out a data review and validation of five key Neglected Tropical Diseases. namely lymphatic filariasis (LF), onchocerciasis (Onco), schistosomiasis (SCH), geohelminthiasis or soil-borne helminths (HTS) and trachoma
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
AbstractTo achieve the elimination of onchocerciasis transmission in all African countries will entail enormous challenges, as has been highlighted by the active discussion around onchocerciasis intervention strategies and evaluation procedures in this journal.Serological thresholds for onchocerciasis elimination, adapted for the African setting, need to be established. The Onchocerciasis Technical Advisory Subgroup of the World Health Organization is currently developing improved guidelines to allow country elimination committees to make evidence-based decisions. Importantly, onchocerciasis-related morbidity should not be...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
by Laura Dean, Rachel Tolhurst, Gartee Nallo, Karsor Kollie, Anthony Bettee, Sally Theobald BackgroundIntegrated disease management, disability and inclusion (DMDI) for NTDs is increasingly prioritised. There is limited evidence on the effectiveness of integrated DMDI from the perspective of affected individuals and how this varies by differing axes of inequality such as age, gender, and disability. We used narrative methods to consider how individuals ’ unique positions of power and privilege shaped their illness experience, to elucidate what practical and feasible steps could support integrated DMDI in Liberia and ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
More News: Filariasis | Infectious Diseases | Partnerships | Research | River Blindness | Tropical Medicine