Research and Reviews in the Fastlane 054

Conclusions Wrong? (emlitofnote) Critical Care, CardiologyGuyton AC. Regulation of cardiac output. Anesthesiology. 1968; 29(2): 314-26. PMID: 5635884 The modern emphasis on echo might make you think that the heart determines cardiac output. This classic paper by Guyton shows that unless the heart is failing, it has a permissive role in determining cardiac output. The real determinants are (1) the degree of vasodilation of the peripheral vasculature, especially veins, and (2) the filling of the circulatory system, indicated by the mean systemic filling pressure. Gotta love those Guyton curves! Recommended by: Chris Nickson Emergency Medicine, Obstetrics/GynecologySlaughter SR et al. FDA approval of doxylamine-pyridoxine therapy for use in pregnancy. NEJM 2014; 370(12): 1081-3. PMID: 24645939 Great editorial on the history and politics of the re-introduction of doxylamine-pyridoxine for N/V of pregnancy in the U.S Recommended by: Jeremy Fried Trauma, Orthopedics Rodriguez L et al. Evidence-based protocol for prophylactic antibiotics in open fractures: Improved antibiotic stewardship with no increase in infection rates. J Trauma Acute Care Surg 2014; 77(3): 400-8. PMID: 25159242 Standard treatment for open fractures with significant tissue damage is variable but typically involves a 1st generation cephalosporin and an aminoglycoside. This study looks at infection rates before and after implementation of an evidence based protocol for prophylactic antibiotics in ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Cardiology Clinical Research Education Emergency Medicine Infectious Disease Intensive Care Neurology Neurosurgery Obstetrics / Gynecology Orthopedics Pediatrics Trauma critical care literature R&R in the FASTLANE recommendat Source Type: blogs