Cardiovascular regulation in response to multiple hemorrhages: analysis and parameter estimation.
Cardiovascular regulation in response to multiple hemorrhages: analysis and parameter estimation. Biol Cybern. 2018 Sep 12;: Authors: Ciocanel MV, Docken SS, Gasper RE, Dean C, Carlson BE, Olufsen MS Abstract Mathematical models can provide useful insights explaining behavior observed in experimental data; however, rigorous analysis is needed to select a subset of model parameters that can be informed by available data. Here we present a method to estimate an identifiable set of parameters based on baseline left ventricular pressure and volume time series data. From this identifiable subset, we then select, based on current understanding of cardiovascular control, parameters that vary in time in response to blood withdrawal, and estimate these parameters over a series of blood withdrawals. These time-varying parameters are first estimated using piecewise linear splines minimizing the mean squared error between measured and computed left ventricular pressure and volume data over four consecutive blood withdrawals. As a final step, the trends in these splines are fit with empirical functional expressions selected to describe cardiovascular regulation during blood withdrawal. Our analysis at baseline found parameters representing timing of cardiac contraction, systemic vascular resistance, and cardiac contractility to be identifiable. Of these parameters, vascular resistance and cardiac contractility were varied in time. Data used for this study were measur...
Authors: Westwood S Abstract With increasing visibility of older lesbian, gay, bisexual and trans (LGBT) people, there is an urgent need to understand abuse in their lives. This is an under-researched area, which this scoping study (based on a literature review and a small subset of data taken from a larger project) serves to demonstrate. The content of this article formed the basis of a paper presented at a workshop on 'LGBT Elder Abuse' held at Keele University(UK) in 2017, convened and chaired by the author. It considers LGBT elder abuse in terms of polyvictimisation, intersectionality and the abuse of power. Th...
Authors: Lhermite A, Munoz Sastre MT, Sorum PC, Mullet E Abstract The views of laypeople and professionals (nurses, occupational therapists, psychologists, and physicians) on the capacity to make informed decisions of elderly people with depression or dementia were examined. Participants were presented with vignettes created by varying the levels of three factors: (a) the type of decision (e.g., agreeing to surgery), (b) the health problem (e.g., slight depression), and (c) the availability of social support. Through cluster analysis, four different positions were found. Seventeen percent of the participants consid...
CONCLUSION:: Reasons for DRF are multifactorial. Preventive strategies with an emphasis on environmental and behavioural factor modifications are likely to decrease the number of DRF. PMID: 30452300 [PubMed - as supplied by publisher]
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