Professor Gerrit Willem (Eddie) Barendsen, August 14, 1927 – June 20, 2018

Professor Eddie Barendsen, also known as “Mr. Linear Quadratic Model,” has peacefully passed away. In the early 1960s, the Holy Grail of radiobiology was to predict the biological and clinical response to radiation using biophysical principles and to describe this dose-response relationship in a mathematical equation. Many radiobiologi cal models came and went, and it took Barendsen more than 20 years to publish what became known as the linear quadratic (LQ) model. In its original version, Barendsen formulated the cellular survival S(D) curve after irradiation dose D as an inverse exponential function dependent on 2 radiobiologic al parameters a1 and a2: S(D)/S(0) = −exp (a1D + a2D2) (1).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Feature Source Type: research