No Apparent Short-Term Cancer Risk From Recalled Valsartan
THURSDAY, Sept. 13, 2018 -- Users of valsartan contaminated with N-nitrosodimethylamine (NDMA) seem not to have increased cancer risk, according to a study published online Sept. 12 in The BMJ. Anton Potteg ård, Ph.D., from the University of...
Cancer stem cells (CSC) play a critical role in tumor recurrence and have been identified in hypoxic zones near necrotic regions with poor vascular supply. Hypericin is a natural compound with fluorescence and necrosis avidity. We developed a dual property nanoplatform with hypericin for necrosis targeting and gold nanocrystals for CT imaging, and evaluated feasibility for therapeutic cell delivery.
The Oncopig Cancer Model (OCM) is a unique transgenic porcine model that develops inducible site and cell specific tumors, and permits in vitro pharmacologic screening using cell lines with the ability to translate promising strategies to in vivo using solid organ tumors. To validate OCM utility for in vitro drug screening, this study tested the hypothesis that OCM and human hepatocellular carcinoma (HCC) cell lines exhibit similar expression of drug-metabolizing enzymes (DMEs) and comparable dose response to standard chemotherapies.
Locoregional therapy lacks the ability to treat systemic disease. Systemic chemotherapy or immunotherapy has significant systemic side effects. Here, we present a proof-of-concept of intra-arterial immunotherapy using saponins (a vaccine adjuvant) in a pig tumor model.
Patients with head and neck cancer (HNC) who present with bleeding events have a high rate of morbidity and mortality. Current data shows mixed outcomes after endovascular interventions. The purpose of this study is to evaluate endovascular interventions for bleeding events in HNC.
The objective of this compound is to decrease the rate of rectal toxicity related to radiation therapy, by creating a gap between the prostate and rectum. Secondary benefits include decreased urinary complications and improved sexual quality of life. The hydrogel spacer maintains space for approximately 3 months, and is absorbed in about 6 months.
To evaluate the efficacy and clinical impact of 3 Tesla in-bore trans-rectal magnetic resonance-guided biopsy (3T MRGB) for prostate cancer (PCa) detection based on PIRADSv2 in patients with either suspected prostate cancer or under active surveillance.
The study was designed to look into venous thromboembolic (VTE) readmission outcomes among inpatients with or without cancer who received an inferior vena cava filter (IVCF).
We describe our experience using MRI fused CBCT guidance for prostate biopsy. There are no published reports on the use of CBCT guidance in prostate biopsies. We hypothesize this technique will have an adequate safety profile while accurately detecting prostate cancer.
Image-guided thermal ablation has become the standard of care for treating early stage liver cancer. However, a significant limitation to a successful ablation procedure is the heat-sink effect, which may lead to suboptimal thermal dose delivery. Currently, there is no reliable method for quantifying the heat-sink effect due to limited information on blood vessel flow and its associated anatomy relative to the ablation zone. The purpose of this study was to use 4D-flow MRI to map out liver flow patterns and correlate flow rates with ablation zone volumes.
Biphenotypic hepatocellular-cholangiocarcinoma (HCC-CC) is a rare type of primary liver cancer that carries a poor prognosis. Since most patients present at a stage too advanced for surgical resection, loco-regional liver directed therapy is often performed for palliative or downstaging purposes. The purpose of this study is to evaluate patient outcomes after Yttrium-90 radioembolization (Y90) in patients with HCC-CC.