Cancers, Vol. 10, Pages 329: Repurposing of Drugs Targeting YAP-TEAD Functions
Cancers, Vol. 10, Pages 329: Repurposing of Drugs Targeting YAP-TEAD Functions
Cancers doi: 10.3390/cancers10090329
Authors:
Gian Marco Elisi
Matteo Santucci
Domenico D’Arca
Angela Lauriola
Gaetano Marverti
Lorena Losi
Laura Scalvini
Maria Laura Bolognesi
Marco Mor
Maria Paola Costi
Drug repurposing is a fast and consolidated approach for the research of new active compounds bypassing the long streamline of the drug discovery process. Several drugs in clinical practice have been reported for modulating the major Hippo pathway’s terminal effectors, namely YAP (Yes1-associated protein), TAZ (transcriptional co-activator with PDZ-binding motif) and TEAD (transcriptional enhanced associate domains), which are directly involved in the regulation of cell growth and tissue homeostasis. Since this pathway is known to have many cross-talking phenomena with cell signaling pathways, many efforts have been made to understand its importance in oncology. Moreover, this could be relevant to obtain new molecular tools and potential therapeutic assets. In this review, we discuss the main mechanisms of action of the best-known compounds, clinically approved or investigational drugs, able to cross-talk and modulate the Hippo pathway, as an attractive strategy for the discovery of new potential lead compounds.
Source: Cancers - Category: Cancer & Oncology Authors: Gian Marco Elisi Matteo Santucci Domenico D ’Arca Angela Lauriola Gaetano Marverti Lorena Losi Laura Scalvini Maria Laura Bolognesi Marco Mor Maria Paola Costi Tags: Review Source Type: research
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