Prevalence of Apolipoprotein E Polymorphisms in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: A Northern Greece Study.

CONCLUSION: In Greece, APOE ε4 presence is related to an increased risk for AD in a dose-related manner. Contrary to long-standing views, men and women with the APOE ε4 genotype have nearly the same odds of developing MCI and AD. PMID: 30205398 [PubMed - as supplied by publisher]
Source: Neuro-Degenerative Diseases - Category: Neurology Authors: Tags: Neurodegener Dis Source Type: research

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ConclusionsThese preliminary results suggest that the newly developed FCSRT version B is equivalent to version A in the main variables tested. Further studies are necessary to ensure interchangeability between versions. We provide normative data for the new version.ResumenIntroducciónEl test Free and Cued Selective Reminding Test (FCSRT) es una prueba de uso extendido para evaluar la memoria episódica verbal, principalmente en el ámbito de la enfermedad de Alzheimer. Existe una versión española de la prueba con datos normativos proveniente del proyecto NEURONORMA.ES. Disponer de versiones...
Source: Neurologia - Category: Neurology Source Type: research
Authors: Niznik JD, Zhao X, He M, Aspinall SL, Hanlon JT, Nace D, Thorpe JM, Thorpe CT Abstract INTRODUCTION: We evaluated the impact of deprescribing acetylcholinesterase inhibitors (AChEIs) on aggressive behaviors and incident antipsychotic use in nursing home (NH) residents with severe dementia. METHODS: We conducted a retrospective study of Medicare claims, Part D, Minimum Data Set for NH residents aged 65+ with severe dementia receiving AChEIs in 2016. Aggressive behaviors were measured using the aggressive behavior scale (ABS; n = 30,788). Incident antipsychotic prescriptions were evaluated among antipsyc...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
BACKGROUND: Learning to walk with a 4-wheeled walker increases cognitive demands in people with Alzheimer's dementia (AD). However, it is expected that experience will offset the increased cognitive demand. Current research has not yet evaluated gait in pe...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Traumatic brain injury (TBI) can cause persistent cognitive changes and ongoing neurodegeneration in the brain. Accumulating epidemiological and pathological evidence implicates TBI in the development of Alzheimer's disease (AD), the most common cause of d...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Conclusion The ability to perform two tasks simultaneously appears to be impaired in patients with Alzheimer ’ s disease, and unaffected by the major depressive disorder.RESUMO Objetivo Avaliar o quanto o desempenho em dupla tarefa pode ser afetado pelo diagn óstico do transtorno depressivo maior (TDM) e pela doença de Alzheimer (DA). Métodos Estudo de corte transversal com 108 indivíduos [Saudáveis (IS) = 56, TDM = 19, DA = 33] com 60 anos ou mais, de ambos os sexos, diagnosticados com doença de Alzheimer, transtorno depressivo maior e sem diagn óstico de doenç...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
ABSTRACT Objectives To evaluate the utility of handgrip strength cut-offs for the identification of weakness and Instrumental Activities of Daily Living (IADL) disability in elderly people with neurocognitive disorders. Methods Cross-sectional study of community-dwelling elderly individuals with Alzheimer ’ s disease (AD, n = 40) and mild cognitive impairment (MCI, n = 22); healthy individuals (n = 36) were recruited as controls. Handgrip cut-offs included European Working Group for Sarcopenic Older People (EWGSOP2), Cardiovascular Healthy Study (CHS) and the Frailty in Brazilian Older People Study from Rio de Janeir...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
Photo credit Matt Botsford It's always an honor to be interviewed by Rosanne Corcoran for Daughterhood.org_thepodcast. Listen to our conversation here but browse the others, as well. Rosanne is a compassionate, knowledgeable interviewer with a natural talent to be sure, but also because she's a compassionate caregiver. Thank you, Rosanne, for this opportunity!   Support a caregiver or jump-start discussion in support groups with real stories - for bulk orders of Minding Our Elders e-mail Carol                  Related StoriesVal...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
AbstractAccurate, automated white matter hyperintensity (WMH) segmentations are needed for large-scale studies to understand contributions of WMH to neurological diseases. We evaluated Bayesian Model Selection (BaMoS), a hierarchical fully-unsupervised model selection framework for WMH segmentation. We compared BaMoS segmentations to semi-automated segmentations, and assessed whether they predicted longitudinal cognitive change in control, early Mild Cognitive Impairment (EMCI), late Mild Cognitive Impairment (LMCI), subjective/significant memory concern (SMC) and Alzheimer ’s (AD) participants. Data were downloaded ...
Source: Neuroinformatics - Category: Neuroscience Source Type: research
The initiative will aim to attract up to £100m in investment by 2030 to support these efforts. 
Source: mobihealthnews - Category: Information Technology Source Type: news
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