Voodoo doll and cannibalism studies triumph at Ig Nobels

Self-colonoscopies, useless instruction manuals, and kidney stones on rollercoasters also among subjects awardedNever mind the protests from health and safety. A research paper that describes how employees can overcome workplace injustice by torturing a voodoo doll that resembles their boss has landed one of the most coveted awards in academia: anIg Nobel prize.The study, which sought to understand why disgruntled staff retaliate against bad superiors – despite the risk of making matters worse – found that tormenting a doll with pins and other implements helped restore their sense of fairness in the world.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Ig Nobel prizes Science prizes Source Type: news

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We describe a case of a 65-year-old woman undergoing hemodialysis treatment since 1986 after a bilateral nephrectomy due to complicated nephrolithiasis. Her last access, two Tesio® tunneled cuffed catheters implanted via the right internal jugular vein functioned correctly for 14 years without complications, and so, was not replaced in the meantime. She was referred to our hospital due to a rupture in a catheter lumen, which was corrected conservatively by creating a more proximal tunnel and excising the affected area. A few weeks later, a new rupture in the same lumen was identified, so the catheter was replace...
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality. The kidney has a unique role not only in protecting the host from heat and dehydration but also is an important site of heat-associated disease. Here we review the potential impact of global warming and heat extremes on kidney diseases. High temperatures can result in increased core temperatures, dehydration, and blood hyperosmolality. Heatstroke (both clinical and subclinical whole-body hyperthermia) may have a major role in causing both acute kidney dise...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
AbstractOxalobacter sp. promotion of enteric oxalate excretion, correlating with reductions in urinary oxalate excretion, was previously reported in rats and mice, but the mechanistic basis for this affect has not been described. The main objective of the present study was to determine whether the apical oxalate transport proteins, PAT1 (slc26a6) and DRA (slc26a3), are involved in mediating theOxalobacter-induced net secretory flux across colonized mouse cecum and distal colon. We measured unidirectional and net fluxes of oxalate across tissues removed from colonized PAT1 and DRA knockout (KO) mice and also across two doub...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Condition:   Kidney Calculi Intervention:   Dietary Supplement: Kroger low calorie orange juice beverage Sponsor:   Indiana University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study's purpose was to determine the role of the NBCe1 A variant (NBCe1-A) in citrate metabolism under basal conditions and in response to acid-loading and hypokalemia. NBCe1-A deletion increased citrate excretion and decreased NaDC1 expression in proximal convoluted tubule (PCT) and proximal straight tubule (PST) in medullary ray (PST-MR), but not in PST in outer medulla (PST-OM). Acid-loading wild-type (WT) mice decreased citrate excretion. NaDC1 expression increased only in PCT and PST-MR, and not in PST-MR. In NBCe1-A KO mice, the acid-loading change in citrate excretion was unaffected, changes in PCT NaDC1 expres...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Nephrolithiasis or renal stone disease is an increasingly common problem, and its relatively high recurrence rate demands for better treatment options. The majority of patients with nephrolithiasis have calcium (Ca2+)-containing stones, which develop upon "supersaturation" of the urine with insoluble Ca2+ salts. Hence, processes that influence the delivery and renal handling of Ca2+ may influence stone formation. Idiopathic hypercalciuria is indeed frequently observed in patients with Ca2+-containing kidney stones.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Review Source Type: research
A man with a history of nephrolithiasis and laparotomy for trauma had left flank and left upper quadrant pain. He had mild leukocytosis, but the physical examination and other laboratory testing were unremarkable; abdominal CT revealed a well-circumscribed, extraluminal mass with central high density. What is the diagnosis and what would you do next?
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
This study demonstrated that the p38 MAPK signaling pathway mediated the COM crystal-induced crystal adhesion change in NRK-52E cells and required the involvement of NLRP3 inflammasome.
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
CONCLUSIONS High consumptions of pickled foods and animal protein were the main risk factors for the development of urolithiasis in a population of southern China, but high fluid intake with a preference for strong tea, a diet of vegetables, and physical exercise were protective factors. PMID: 31170122 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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