Genetically Engineered Mouse-Derived Allograft for Preclinical Studies of Metastatic Melanoma

The invention listed below is owned by an agency of the U.S. Government and is available for licensing and/or co-development in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development.Before testing drugs in humans, drug developers are required to demonstrate a reasonable expectation of safety and efficacy by performing so-called pre-clinical studies.   A key element of such trials is the use of animal models, typically mice or rats that are selected for demonstrating hallmarks of a given disease.  For cancer research, while many mouse models exist to simulate the response of the cancer to a particular drug, all of the current models have some limitations in their ability to fully predict the concomitant physiological or immunological response that might result when the drug progresses to clinical trials.  This is problematic both in models in which the cancer spontaneously develops in the animal as well as models in which cancerous cell s or tumors, i.e. allografts (derived from cells of the same organism) or xenografts (derived from cells of different organism, usually humans) are transplanted into an otherwise cancer-free animal. To address these issues, researchers at NCI have developed a means of more closely simulating in mouse models both melanoma cancer itself and the resulting physiological an immunological response by creating a genetically engineered mice (GEM...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research