Targeted RNA/DNA Nanoparticles with Single Stranded RNA Toeholds

The development of RNA-based nanostructures and their use in a variety of applications, including RNA interference (RNAi) and drug delivery, represents an emerging field of science, technology, and biomedicine.   RNA is a dynamic material because of its natural functionalities, its ability to fold into complex small structures, and its capacity to self-assemble.  Taking advantage of these characteristic, NCI Researchers have improved upon their existing invention of multi-functional RNA/DNA nanoparticles by adding a RNA toehold instead of a DNA toehold.   In in vitro studies, they have shown that the nanoparticles are capable of inhibiting HIV-1 gene expression in Hela cells transfected with a HIV-1 infectious clone and GFP expression in MDA-MB231 breast cancer cell lines transfected with eGFP. IC: NCINIH Ref. No.: E-078-2016Advantages: Small sizeChemical stabilityLess immunogenicApplications: Therapeutic siRNA for cancer, CNS, and viral infectionsDiagnostic to visualize cancerous or virus-infected cellsIncreasing market for RNA-based therapeutics expected to continue by>25% annually through 2020Development Status: Pre-clinical (in vivo)Updated On: Jul 27, 2018Provider Classifications: Date Published: Friday, July 27, 2018Publications: Patent Application: PCT/US2016/017661Licensing Contacts: Lead Inventor: Inventor IC: NCILPM FIrst Name: JohnLPM Last Name: HewesInv Is lead: LPM Phone: ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research