Considerations for using Natalizumab treatment in patients with a history of choroidal melanoma

Publication date: Available online 12 September 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Abigail E. Kaye, Elizabeth D. Hawkes, Irina I. Gout, Ahmed N. El-Amir, James E. NeffendorfAbstractNatalizumab is a monoclonal antibody licensed for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is known to increase the potential risk of developing progressive multifocal leukoencephalopathy (PML). There is current debate in the literature regarding its association with malignant melanoma. Herein, we report a case of a 55-year old lady with RRMS for whom natalizumab therapy was being considered by her neurologist. Her medical history included a choroidal melanoma which had undergone successful treatment. Additionally, in this case study we discuss the issues regarding malignant melanoma risk and recurrence with natalizumab treatment.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research