Nail Involvement as a Predictor of Disease Severity in Paediatric Psoriasis: Follow-up Data from the Dutch ChildCAPTURE Registry.

Nail Involvement as a Predictor of Disease Severity in Paediatric Psoriasis: Follow-up Data from the Dutch ChildCAPTURE Registry.
Acta Derm Venereol. 2018 Sep 12;:
Authors: Bronckers IMGJ, Bruins FM, van Geel MJ, Groenewoud HMM, Kievit W, van de Kerkhof PCM, Pasch MC, de Jong EMGJ, Seyger MMB
Abstract
Little is known about the relationship between nail psoriasis and psoriasis severity in children, and there has been no longitudinal assessment of psoriasis severity related to nail psoriasis. The aim of this study was to assess whether nail psoriasis could serve as a predictor for a more severe disease course. De-identified data were obtained from the Child-CAPTURE registry, a daily clinical practice cohort of children with psoriasis, from September 2008 to November 2015. Cross-sectional analyses were performed at baseline. Longitudinal data until 2-year follow-up were analysed by linear mixed models. Nail psoriasis was present in 19.0% of all 343 patients at baseline and cross-sectionally associated with higher Psoriasis Area and Severity Index (PASI) (p = 0.033). Longitudinal analysis demonstrated higher PASI (p < 0.001) during 2-year follow-up in patients with nail involvement at baseline. These findings suggest that nail psoriasis is a potential clinical predictor for more severe disease course over time in paediatric psoriasis.
PMID: 30206638 [PubMed - as supplied by publisher]

Source: Acta Dermato-Venereologica - September 12, 2018 Category: Dermatology Authors: Bronckers IMGJ, Bruins FM, van Geel MJ, Groenewoud HMM, Kievit W, van de Kerkhof PCM, Pasch MC, de Jong EMGJ, Seyger MMB Tags: Acta Derm Venereol Source Type: research