Scientists Are Developing New Ways to Treat Disease With Cells, Not Drugs

When Nichelle Obar learned she was pregnant with her second child last year, she never expected that her pregnancy, or her baby, would make history. But when the 40-year-old food-and-beverage coordinator from Hawaii and her fiancé Christopher Constantino went to their 18-week ultrasound, they learned something was wrong. The heart was larger than it should have been, and there was evidence that fluid was starting to build up around the organ as well. Both were signs that the fetus was working extra hard to pump blood to its fast-growing body and that its heart was starting to fail. Obar’s doctor knew what could be causing it. Obar and Constantino are both carriers of a genetic blood disorder called alpha thalassemia, which can lead to dangerously low levels of red blood cells. Red blood cells carry hemoglobin, which binds to oxygen and transports it from the lungs to feed other cells–so fewer red blood cells means low levels of oxygen in cells throughout the body. Neither parent is affected by the condition, but depending on how their genes combined, their children could be. When Obar was pregnant with their first child, Gabriel, the couple was told that if he had the disease, his prognosis would be grim. “The information we got was that most babies don’t survive, and if they do survive to birth, they might not live for too long,” Obar says. Gabriel was lucky. The DNA he inherited from his mom and dad did not endow his cells with enough o...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized medicine Source Type: news

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CONCLUSIONS Matricine induced antiproliferative effects in capan-2 human pancreatic cancer cells through inducing apoptosis, caspase activation, inhibition of cell migration and invasion, and blocking the mTOR/PI3K/AKT signalling pathway. PMID: 31005960 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS In conclusion, in view of the results of this study, it might be suggested that ferruginol might serve as an essential lead molecule for the treatment of thyroid cancer provided further in-depth studies especially studying ferruginol toxicological as well as in vivo studies are needed. PMID: 31005958 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Tian S, Yan Y, Qi X, Li X, Li Z Abstract BACKGROUND Rheumatoid arthritis model (CIA) rats were treated by tail vein injection of IL-10-modified bone marrow mesenchymal stem cells (BMSCs) to investigate its feasibility and intrinsic molecular mechanism. MATERIAL AND METHODS The CIA rat model was established by induction type II collagen, and IL-10-modified BMSCs was established by transfecting BMSCs with adenovirus. IL-10-modified BMSCs were used to treat the CIA rats. The therapeutic effect was evaluated by measuring the changes in body weight, ankle swelling, and forced swimming time, as well as observati...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionThis review finds camel milk insulin as an effective nutraceutical on pathophysiological and molecular grounds.
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 21 April 2019Source: Trends in Food Science &TechnologyAuthor(s): Zengling Ma, Faruq Ahmed, Bo Yuan, Wei ZhangAbstractBackgroundArthrospira (Spirulina) spp. has long been consumed as a dietary supplement that provides rich natural nutrients consisting of 60-70% proteins including essential amino acids, vitamins, and some minerals. The currently available Spirulina products in the market are mainly hot and spray-dried and their nutritional values are significantly compromised due to degradation of the heat-sensitive bioactive components.Scope and approachThis commentary provides a crit...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Abstract This review discusses the epidemiologic and clinical aspects of herpes viruses other than cytomegalovirus in patients who have undergone hematopoietic stem cell transplantation. PMID: 31005137 [PubMed - in process]
Source: Herpes - Category: Infectious Diseases Authors: Tags: Infect Dis Clin North Am Source Type: research
by Arthur Caplan, Ph.D. Researchers at Yale University recently reported an experiment in which they used an experimental chemical solution to create electrical activity in the cells of pig brains, brains obtained from a slaughterhouse four hours after the death of the animals from decapitation (NY Times ‘Partly Alive’: Scientists Revive Cells in Brains From Dead Pigs, 4/17,19).  These results led to all manner of comments in this story, many from bioethicists and in stories elsewhere.  Commentators suggested that the pigs’ brains were somehow made partly alive, that concerns about consciousness...
Source: - Category: Medical Ethics Authors: Tags: Animal Ethics Clinical Trials & Studies End of Life Care Featured Posts Organ Transplant & Donation Research Ethics Science Source Type: blogs
Publication date: Available online 21 April 2019Source: Biotechnology ReportsAuthor(s): Igor A de Souza, Daniela C Orsi, Anderson J Gomes, Claure N LunardiAbstractThe use of alginate and chitosan polymer in the immobilization of Aspergillus oryzae ATCC 3940 fungal crude enzyme extract (CEE) amylase was presented. The assembly results change in the application of optimal pH and temperature hydrolysis to convert starch to sugar. Bead arrangement in three microgel supports: the internal support phase (IP), the external support phase (EP), and the internal and external support phase (UP). The best results were obtained using I...
Source: Biotechnology Reports - Category: Biotechnology Source Type: research
Should we abandon the term〝lone atrial fibrillation〞? Hellenic J Cardiol. 2019 Apr 17;: Authors: Lin KB, Marine JE, Calkins H, Nazarian S, Wei M, Huang MD, Li JB Abstract Characterized by lack of evidence of structural heart disease or any secondary causes of atrial fibrillation (AF), "lone AF" used to represent a unique subtype of AF among the young individuals who were under the age of 60. Despite the longstanding definition has been proposed for years, the diagnostic criteria for "lone AF" remain ambiguous. As more contributing factors causing AF are recognized gradually, the...
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
Publication date: Available online 21 April 2019Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Saverio Candido, Massimo Libra, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Weifeng Mao, Heng-Liang LinAbstractPancreatic cancer is devastating cancer worldwide with few if any truly effective therapies. Pancreatic cancer has an increasing incidence and may become the sec...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
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