The independent and joint associations of physical activity and body mass index with myocardial infarction: The Tromsø Study

Publication date: Available online 13 September 2018Source: Preventive MedicineAuthor(s): Marius Renninger, Maja-Lisa Løchen, Ulf Ekelund, Laila A. Hopstock, Lone Jørgensen, Ellisiv B. Mathiesen, Inger Njølstad, Henrik Schirmer, Tom Wilsgaard, Bente MorsethAbstractPhysical activity and overweight are associated with myocardial infarction (MI). However, their joint association with MI remains unclear. Our objective was to examine the independent and joint association between leisure-time physical activity (LTPA), body mass index (BMI) and MI. This prospective cohort study included 16,572 men and women (47.5% women) aged 20–54 years who took part in the second Tromsø Study. At baseline in 1979–80 LTPA was assessed by questionnaire. Data on MI was collected and adjudicated through hospital and causes of death registries between 1979 and 2013. Cox proportional hazards models were used to examine the independent and joint associations between LTPA, BMI and MI. The final sample included 16,104 individuals. During a median follow up of 34 years, 1613 incident cases of MI were recorded. Physical inactivity and elevated BMI were both independently associated with MI (p for trend 0.02 and <0.001). In joint analyses, normal weight, inactive individuals had a 20% higher risk of MI compared to their active counterparts (hazard ratio (HR) 1.20 (1.02–1.41)). The highest risk of MI was seen in obese, inactive individuals when compared to normal weight, active individuals (H...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research