Rhubarb Protect Against Tubulointerstitial Fibrosis by Inhibiting TGF- β/Smad Pathway and Improving Abnormal Metabolome in Chronic Kidney Disease

Zhi-Hao Zhang, Ming-Hua Li, Dan Liu, Hua Chen, Dan-Qian Chen, Ning-Hua Tan, Shuang-Cheng Ma, Ying-Yong Zhao
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

Related Links:

Publication date: Available online 6 May 2019Source: Journal of Evidence Based Dental PracticeAuthor(s): Shanika Nanayakkara, Xiaoyan ZhouArticle Title and Bibliographic InformationThe directional and nondirectional associations of periodontitis with chronic kidney disease: A systematic review and meta-analysis of observational studies. Zhao D, Khawaja AT, Jin L, Li K–Y, Tonetti M, Pelekos G. J Perio Res 2018; 53(5):682-704.Source of FundingThe authors' own institution, University of Hong Kong.Type of Study/DesignSystematic review with meta-analysis of data.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
The objective of this review is to know what is available in the literature on the dose of heat disinfection that should be used in hemodialysis and to present our experience with this method at a set dose of 12.000 A0. PMID: 31109712 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Authors: Garla VV, Kanduri S, Yanes-Cardozo L, Lien LF Abstract Diabetes mellitus (DM) and Chronic Kidney Disease (CKD) are two chronic diseases whose prevalence and co-prevalence are on the rise. CKD is also the most debilitating and expensive complication of DM while management of DM in CKD is most challenging. CKD is developing in much younger patients with DM, and its presentation is also changing. Various methods of glycemic assessment are affected by CKD and dosage of DM medications needs to be adjusted according to the kidney function. One of the significant barriers to glycemic control in DM patients with C...
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
AbstractPurpose of ReviewDespite enhanced screening and therapeutic management, hypertension remains the most prevalent chronic disease in the United States and the leading cause of heart disease, chronic kidney disease, and stroke in both men and women. It is widely accepted that hypertension is a pro-inflammatory disease and that the immune system plays a vital role in mediating hypertensive outcomes and end organ damage. Despite known discrepancies in the risk of hypertension development between men and women, preclinical models of immune-mediated hypertension were historically developed solely in male animals, leading ...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
AbstractStrongyloides stercoralis (S. stercoralis), a human intestinal nematode, can lead to hyper/disseminated (HD) infection in patients treated with corticosteroids. Here, we report a case of strongyloidiasis in a 58-year-old female with a history of rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). The patient presented with abdominal pain and gastrointestinal (GI) bleeding. Stool was negative for parasitic agents in the first direct smear examination, and the patient with the probable diagnosis ofHelicobacter pylori (H. pylori) infection or Crohn ’s disease received antibiotics and corticosteroids. ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to emphasize the pivotal role of glucagon-like peptide 1 (GLP-1) in tackling the parallel epidemics of obesity and type 2 diabetes (T2DM).Recent FindingsGLP-1-based therapies and in particular GLP-1 receptor agonists (GLP-1 RA) have proven to be effective in lowering blood glucose and decreasing weight. GLP-1 RA not only mitigate these significant medical burdens but also result in weight loss and weight loss independent factors that decrease cardiovascular disease (CVD) and microvascular complications of T2DM, such as diabetic nephropathy.SummaryGLP-1-based therapies ...
Source: Current Obesity Reports - Category: Eating Disorders & Weight Management Source Type: research
AbstractThe purpose of this study was to investigate the correlation between left atrial (LA) strain and alterations in cardiac diastolic function in patients with end-stage renal disease. 59 patients with stage 5 chronic kidney disease  (CKD5) and 30 healthy controls were enrolled in this study. Patients with CKD5 were divided into three groups, from normal to Grade II diastolic dysfunction. LA longitudinal strain was evaluated using two-dimensional speckle tracking echocardiography. The peak LA longitudinal strain values (PALS) and LA stiffness index were recorded as the main parameters. Comparing with control group...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
AbstractBackgroundStable ischemic heart disease (SIHD) is prevalent in patients with chronic kidney disease (CKD); however, whether guideline-directed medical therapy (GDMT) is adequately implemented in patients with SIHD and CKD is unknown.HypothesisUse of GDMT and achievement of treatment targets would be higher in SIHD patients without CKD than in patients with CKD.MethodsThis was a retrospective study of 563 consecutive patients with SIHD (mean age 67.8  years, 84% Caucasians, 40% females). CKD was defined as an estimated glomerular filtration rate (eGFR) of
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Abstract OBJECTIVE: To report the spectrum of ethambutol induced optic neuropathy in a group of renal patients with tuberculosis and the role of visual evoked response (VER) in evaluating this disorder. METHODS: Twenty-three renal patients who were started on ethambutol as a part of anti-tubercular treatment for tuberculosis in India, were divided into 4 groups based on glomerular filtration rate (GFR): group 1-chronic kidney disease (CKD) with GFR 30 ≤ 60 mL/min; and group 4-GFR> 60
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Conclusions: Enarodustat corrected and maintained Hb levels in anemic patients with hemodialysis-dependent CKD. Phase 3 studies of enarodustat are currently ongoing.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
More News: Chronic Kidney Disease | Drugs & Pharmacology | Rhubarb | Urology & Nephrology