Chloroquine analogues as leads against Pneumocystis lung pathogens.

Chloroquine analogues as leads against Pneumocystis lung pathogens.
Antimicrob Agents Chemother. 2018 Sep 10;:
Authors: Gomes A, Ferraz R, Ficker L, Collins MS, Prudêncio C, Cushion MT, Teixeira C, Gomes P
Abstract
The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, auto-immune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii, in vitro Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.
PMID: 30201816 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - September 10, 2018 Category: Microbiology Authors: Gomes A, Ferraz R, Ficker L, Collins MS, Prudêncio C, Cushion MT, Teixeira C, Gomes P Tags: Antimicrob Agents Chemother Source Type: research