Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study

Publication date: Available online 11 September 2018Source: Saudi Pharmaceutical JournalAuthor(s): Abdulrahman A. Almehizia, Hatem H. Abuelizz, Hanan A.A. Taie, Anouar ElHassane, Mohamed Marzouk, Rashad Al-SalahiAbstractPreviously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1-16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1-16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds 1 and 14 have shown the highest activity. The butylated hydroxyl toluene (BHT) used as positive control agent.Density functional theory was carried out to explain the relative importance of C=O, C=S and NH groups on the radical scavenging activity of the target benzotriazoloquinazolines. The finding in present study shows that the active compounds can be used as template for further development of more potent antioxidant agents.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research