Cohort Differences in Cognitive Impairment and Cognitive Decline among Mexican-Americans Aged 75 and Older.

Cohort Differences in Cognitive Impairment and Cognitive Decline among Mexican-Americans Aged 75 and Older. Am J Epidemiol. 2018 Sep 07;: Authors: Downer B, Garcia MA, Raji M, Markides KS Abstract Research suggests the prevalence and incidence of cognitive impairment among older adults is decreasing. This analysis used data from nine waves (1993-2016) of the Hispanic Established Populations for the Epidemiologic Study of the Elderly to assess the cognitive status and cognitive decline for two cohorts of Mexican-Americans aged ≥75 in 1993/94 versus 2004/05. Logistic regression, joint longitudinal-survival models, and illness-death models for interval-censored data were used to examine cohort differences in the odds of prevalent cognitive impairment, trajectories of cognitive decline, and the risk for 10-year incident cognitive impairment, respectively. Results indicated that compared to the 1993/94 Cohort, the 2004/05 Cohort had higher odds for prevalent cognitive impairment (odds ratio: 2.51, 95% confidence interval [CI]: 1.92, 3.29), particularly among participants with <4 years of education (odds ratio:2.99 95% CI: 2.14, 4.18). Conversely, the 2004/05 Cohort exhibited significantly slower rates of cognitive decline (βˆ: 0.50, 95% CI: 0.39, 0.62) and had a significantly lower risk for incident cognitive impairment (hazard ratio: 0.75, 95% CI: 0.62, 0.91) compared to the 1993/94 Cohort. This analysis provides mixed results for...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research