Noradrenergic Mechanisms Controlling Urethral Smooth and Striated Muscle Function in Urethral Continence Reflex in Rats

ConclusionThese results suggest that: the baseline activity and reflex contraction of urethral smooth muscle are decreased by α1‐AR inhibition or α2‐AR stimulation; the reflex contraction of urethral striated muscle is decreased by α2‐AR stimulation, but not by α1‐AR inhibition; and nisoxetine increases baseline and reflex activity of smooth muscle in addition to striated muscle reflex activity by α1‐AR stimulation. These findings will be useful to understand nerve‐mediated urethral closure mechanisms.

Source: LUTS: Lower Urinary Tract Symptoms - July 7, 2014 Category: Urology & Nephrology Authors: Akira FURUTA, Yasuyuki SUZUKI, Shouji KIMURA, Kouji ASANO, Shin EGAWA, Naoki YOSHIMURA Tags: ORIGINAL ARTICLE Source Type: research