Susceptible period for cardiovascular complications in patients recovering from sepsis.

Susceptible period for cardiovascular complications in patients recovering from sepsis. CMAJ. 2018 Sep 10;190(36):E1062-E1069 Authors: Lai CC, Lee MG, Lee WC, Chao CC, Hsu TC, Lee SH, Lee CC, National Taiwan University Hospital Health Data Science Research Group Abstract BACKGROUND: Patients are at increased risk of cardiovascular complications while recovering from sepsis. We aimed to study the temporal change and susceptible periods for cardiovascular complications in patients recovering from sepsis by using a national database. METHODS: In this retrospective population-based cohort study, patients with sepsis were identified from the National Health Insurance Research Database in Taiwan. We estimated the risk of myocardial infarction (MI) and stroke following sepsis by comparing a sepsis cohort to a matched population and hospital control cohort. The primary outcome was first occurrence of MI or stroke requiring admission to hospital during the 180-day period following discharge from hospital after sepsis. To delineate the risk profile over time, we plotted the weekly risk of MI and stroke against time using the Cox proportional hazards model. We determined the susceptible period by fitting the 2 phases of time-dependent risk curves with free-knot splines, which highlights the turning point of the risk of MI and stroke after discharge from the hospital. RESULTS: We included 42 316 patients with sepsis; stroke devel...
Source: cmaj - Category: General Medicine Authors: Tags: CMAJ Source Type: research