Wake Forest Baptist receives federal grants to study neurological disorders and stroke

(Wake Forest Baptist Medical Center) The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), has awarded Wake Forest Baptist Medical Center two five-year grants, each worth approximately $1.5 million, to participate in two nationwide clinical trial networks.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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This study provides evidence that CAS is a valid and effective treatment option regardless of whether patients exhibited ROAF or not. Patients without ROAF were significantly more likely to have improved mid-term functional outcomes compared to those with ROAF. In the group without ROAF admission, CRP may play a role in predicting subsequent functional outcomes, whereas admission Barthel Index was a predictor of outcome in the ROAF group. PMID: 30433861 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Authors: Liu G, Dong M, Ma S, Fu L, Xiao Y, Zhong L, Geng J Abstract OBJECTIVE: Leptin may be associated with cardiovascular disease. We tested to determine whether leptin is a marker for first-ever acute ischemic stroke (AIS) in a nested case-referent study. METHODS: Consecutive patients with first-ever AIS from May 2017 to December 2017 were included. Referents were matched for sex, age and body mass index. Serum leptin levels and routine tests were examined in both groups. RESULTS: The median serum level of leptin in the stroke patients was 14.3 (interquartile range [IQR], 7.2-21.7) ng/ml, which was significantly higher (P
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
This study included 172 consecutive patients with their first acute MI, 88 STEMI, and 84 NSTEMI, treated with PCI. On the third day of hospitalization, blood samples were collected from each patient to measure the concentration of clopidogrel and its metabolite 2-oxo-clopidogrel using the UHPLC-DAD-MS method. The following clinical outcomes were registered during the 28-month follow-up: mortality from cardiovascular causes, nonfatal MI, nonfatal stroke, and hospitalization for urgent myocardial revascularization or heart failure. RESULTS: Lower dose-adjusted clopidogrel concentrations (p 
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Conclusions Patients with Guillain-Barré syndrome, multiple sclerosis, Parkinson disease, and stroke should improve during inpatient rehabilitation but anticipated outcomes for patients with Guillain-Barré syndrome should be even higher.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
Conclusions Functional status can provide some objectivity to the largely subjective assistive device provision decision-making process; however, many other factors must be considered simultaneously, complicating efforts to standardize provision.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
“AI and machine learning are going to transform healthcare, as they have virtually every other industry they have touched,” said Gene Saragnese, chairman and CEO of MaxQ AI in an interview with MD+DI. “Our world is surrounded by algorithms that present information, but one place it’s been lacking is healthcare.” MaxQ AI is doing its best to remedy that deficiency, starting with software that can detect intracranial hemorrhage (ICH). The company’s recently FDA-cleared Accipio Ix is used with noncontrast co...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
ConclusionsPooled analysis showed a significantly high prevalence of stroke (10%) inRS2200733 AF patients. AF patients with the studied SNPs had preserved left ventricular systolic function (i.e., ejection fraction greater than 50%). AF patients withRS10033464 presented larger left atrium diameter (44  mm (95% CI 42.02–45.98)) than those with other SNPs. The late AF recurrence rate was highest inRS2200733 patients (53% (95% CI 0.43 –0.64)). This study aids our understanding of the existing genetic findings and the function-altering “strongest” SNPs.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
This study serves as a foundation to better understand how resting‐state fMRI can assess motor functional connectivity and potentially be applied to explore mechanisms of interventional therapies after perinatal stroke.
Source: Human Brain Mapping - Category: Neurology Authors: Tags: RESEARCH ARTICLE Source Type: research
In conclusion, most patients had achieved the target INR at the time of ICH, and the primary precipitant of fatal ICH was often a fall. Using DOACs instead of warfarin and implementing structured fall-prevention programs in high-risk patients could further reduce mortality from ICH in AF.
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
DiscussionThe results of this systematic review will summarise the strength of evidence for rehabilitation interventions used in the rehabilitation of physical function and immobility-related complications in severe stroke and identify gaps in evidence.Systematic review registrationThe systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) —registration numberCRD77737.
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
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