PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes
Gawden-Bone et al. show that during immune synapse formation, rapid depletion of PIP5K at the synapse triggers subsequent changes in membrane composition and actin dynamics to establish a zone of localized granule secretion.
Source: Immunity - Category: Allergy & Immunology Authors: Christian M. Gawden-Bone, Gordon L. Frazer, Arianne C. Richard, Claire Y. Ma, Katharina Strege, Gillian M. Griffiths Tags: Article Source Type: research
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