PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes

Gawden-Bone et  al. show that during immune synapse formation, rapid depletion of PIP5K at the synapse triggers subsequent changes in membrane composition and actin dynamics to establish a zone of localized granule secretion.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Article Source Type: research