Proof-of-Concept Preparation and Characterization of Dual-Drug Amorphous Nanoparticle Complex as Fixed-Dose Combination of Poorly Soluble Drugs.

CONCLUSION: Dual-drug nanoplex was successfully prepared with high degree of control over its physical characteristics. Nevertheless, whether dual-drug nanoplex always exhibits diminished solubility enhancement compared to its single-drug counterparts needs to be investigated using different poorly-soluble drugs. PMID: 30196726 [PubMed - as supplied by publisher]
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research