Surgery for Mesothelioma No Longer Recommended in UK

Aggressive surgery for the treatment of malignant pleural mesothelioma (MPM) — unless part of a clinical trial — is no longer being recommended in the United Kingdom. The British Thoracic Society recently published its Mesothelioma Management Guidelines for 2018 and removed surgery from its recommendations. The belief was that potential harm was not worth the risk. The backtrack on surgery included the extrapleural pneumonectomy (EPP), the extended pleurectomy and decortication (P/D) and the partial pleurectomy (PP) — all of which are being done at cancer centers in the United States. “Surgery is a controversial area. There is a difference of opinion, from our practice in the U.K. and much of Europe, than the practice in the [United] States,” Dr. Anna Bibby, Bristol Medical School and Southmead Hospital in Bristol, United Kingdom, told Asbestos.com. “American guidelines are more encouraging of surgery. It comes down to how evidence is interpreted, assessing harm and benefits.” Study Looks at the Future of Treatment Bibby is the lead author of a recently published study in the Clinical Respiratory Journal that reviewed hundreds of clinical trials and studies over the past three decades. It includes current ones. The study provided a look at potential future treatment options. Some of the trials also were used by the British Thoracic Society in making its latest recommendations. Of the 258 studies, 35 were selected for inclusion in th...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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elli Varesano Malignant pleural mesothelioma (MPM) is a rare neoplasm related to asbestos exposure and with high mortality rate. The management of patients with MPM is complex and controversial, particularly with regard to early diagnosis. In the last few years, breath analysis has been greatly implemented with this aim. In this review the strengths of breath analysis and preliminary results in searching breath biomarkers of MPM are highlighted and discussed, respectively. Through a systematic electronic literature search, collecting papers published from 2000 until December 2018, fifteen relevant scientific papers ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
The House Judiciary Committee passed the Never Forget the Heroes bill Wednesday that will extend the 9/11 Victim Compensation Fund until 2090. The bill would ensure all victims of the Sept. 11 terrorist attacks — and their families — will be compensated throughout their lives. It now must pass the full House of Representatives and the Senate before it can be signed into law by the president. The extension would especially help any 9/11 victims, first responders or bystanders that may develop mesothelioma linked to the estimated 400 tons of asbestos that was released in New York City after the twin towers fell....
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
At the 2019 American Society of Clinical Oncology annual meeting, Dr. Prasad Adusumilli from Memorial Sloan Kettering Cancer Center shared exciting new results from his study on combination immunotherapy for malignant pleural mesothelioma. Among the 18 mesothelioma patients in the study, 14 received a combination of two different immunotherapy treatments. Eleven of this group experienced a complete response, a partial response or stable disease. The latest results from this phase 1 clinical trial were presented June 4. They demonstrate the promise of using two immunotherapy approaches at one time. Phase 1 studies are desi...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Conditions:   Breast Cancer;   Epithelial Ovarian Cancer;   Cervical Cancer;   Pancreatic Cancer;   Endometrial Cancer;   Renal Cancer;   Urothelial Cancer;   Head and Neck Cancer;   Mesothelioma;   Melanoma;   Hepatic Carcinoma;   Prostate Cancer;   NSCLC Intervention:   Combination Product: Naptumomab estafenatox (ABR-217620; Nap) with durvalumab (IMFINZI; MEDI4736) Sponsors:   NeoTX Therapeutics Ltd.;   AstraZeneca Pharmaceuticals PLC Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Regardless of the approach, RPLND may provide a diagnostic benefit in patients who present with MMTVT, with the robotic approach affording a potentially expedited recovery. PMID: 31180304 [PubMed - in process]
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
Too many patients with pleural mesothelioma are going without treatment recommended by National Comprehensive Cancer Network guidelines, according to a recent study at Cedars-Sinai Medical Center in Los Angeles. Valuable survival time is being lost. The Annals of Thoracic Surgery published the study that looked at disparities in compliance with national treatment guidelines and their impact on overall survival. The National Comprehensive Cancer Network, along with the American Society of Clinical Oncology, recommends multimodal therapy — surgery, chemotherapy and possibly radiation therapy — for mesothelioma pa...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Hidetaka Uramoto It is not clear whether magnetic resonance imaging (MRI) is useful for the assessment of pleural diseases. The aim of this study is to determine whether diffusion-weighted magnetic resonance imaging (DWI) can differentiate malignant pleural mesothelioma (MPM) from pleural dissemination of lung cancer, empyema or pleural effusion. The DWI was calibrated with the b value of 0 and 800 s/mm2. There were 11 MPMs (8 epithelioid and 3 biphasic), 10 pleural disseminations of lung cancer, 10 empyemas, and 12 pleural effusions. The apparent diffusion coefficient (ADC) of the pleural diseases was 1.22 &plu...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Purpose of review Malignancy accounts for a substantial proportion of pleural effusions, and cytologic examination of pleural fluid is the easiest way to establish the diagnosis. This review summarizes relevant advances in the diagnostic cytopathology of pleural effusions for the practicing pulmonologist. Recent findings Cytologic analysis using a stained smear and cell block preparation is able to provide the diagnosis in about 55% of malignant effusions. Processing a maximum of two separate specimens (provided the initial examination is negative) with an approximate volume of 40 ml each is the most accepted recomm...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: DISEASES OF THE PLEURA: Edited by Richard Light Source Type: research
For the second time in three months, Claire’s stores issued a voluntary recall over concerns of asbestos contamination in its makeup products marketed to young girls, the U.S. Food and Drug Administration announced late Thursday. Claire’s, a children’s fashion accessory retail chain found in malls across the U.S., has recalled its JoJo Siwa Makeup Set (SKU #888711136337, Batch/Lot No. S180109) after the product tested positive for asbestos during the FDA’s ongoing investigation of asbestos contamination in cosmetics. Exposure to asbestos dust can cause serious health conditions decades later, inclu...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
For the second time in three months, Claire’s stores issued a voluntary recall over concerns of asbestos contamination in its makeup products marketed to young girls, the U.S. Food and Drug Administration announced late Thursday. Claire’s, a children’s fashion accessory retail chain found in malls across the U.S., has recalled its JoJo Siwa Makeup Set (SKU #888711136337, Batch/Lot No. S180109) after the product tested positive for asbestos during the FDA’s ongoing investigation of asbestos contamination in cosmetics. Exposure to asbestos dust can cause serious health conditions decades later, inclu...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
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