Transposons, p53 and Genome Security.

Transposons, p53 and Genome Security. Trends Genet. 2018 Sep 05;: Authors: Tiwari B, Jones AE, Abrams JM Abstract p53, the most commonly mutated tumor suppressor, is a transcription factor known to regulate proliferation, senescence, and apoptosis. Compelling studies have found that p53 may prevent oncogenesis through effectors that are unrelated to these canonical processes and recent findings have uncovered ancient roles for p53 in the containment of mobile elements. Together, these developments raise the possibility that some p53-driven cancers could result from unrestrained transposons. Here, we explore evidence linking conserved features of p53 biology to the control of transposons. We also show how p53-deficient cells can be exploited to probe the behavior of transposons and illustrate how unrestrained transposons incited by p53 loss might contribute to human malignancies. PMID: 30195581 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30195581?dopt=Abstract

Source: Trends in Genetics : TIG - September 5, 2018 Category: Genetics & Stem Cells Authors: Tiwari B, Jones AE, Abrams JM Tags: Trends Genet Source Type: research