Chronic Interleukin-1β in the Dorsal Hippocampus Impairs Behavioural Pattern Separation

In conclusion, these findings suggest that chronically elevated IL-1β in the hippocampus selectively impairs pattern separation. Inflammatory-mediated disruption of adult neurogenesis may contribute to the cognitive decline associated with neurodegenerative and stress-related disorders.

Source: Brain, Behavior, and Immunity - September 11, 2018 Category: Neurology Source Type: research