Single-Nucleotide Polymorphisms in TAOK3 Are Associated With High Opioid Requirement for Pain Management in Patients With Advanced Cancer Admitted to a Tertiary Palliative Care Unit

Different amounts of opioid are required for the relief of cancer pain in different individuals, raising the possibility that genetic factors play a role. We tested the hypothesis that genetic variations in the TAOK3 (TAO kinase 3, encoding serine/threonine-protein kinase) explain some of the interindividual variations related to the morphine-equivalent daily dose (MEDD) in patients with cancer.

Source: Journal of Pain and Symptom Management - July 19, 2018 Category: Palliative Care Authors: Timothy Gutteridge, Mahalakshmi Kumaran, Sunita Ghosh, Robin Fainsinger, P ål Klepstad, Yoko Tarumi, Sambasivarao Damaraju, Vickie E. Baracos Tags: Brief Report Source Type: research