Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone cores formation in mice

Gallstone diseases have various symptoms, including pain and fever, and can lead to life-threatening conditions such as acute cholangitis, acute cholecystitis, biliary pancreatitis, and cancer of the biliary tract.[1,2] Given that gallstone diseases have a high incidence rate, are costly to treat surgically, and are responsible for lost work hours due to symptoms, preventing these diseases should have deep impacts on health and society.[1]

Source: Journal of Hepatology - September 10, 2018 Category: Gastroenterology Authors: Hiroo Tanaka, Mitsunobu Imasato, Yuji Yamazaki, Kengo Matsumoto, Koshi Kunimoto, Julien Delpierre, Kirstin Meyer, Marino Zerial, Naho Kitamura, Mitsuhiro Watanabe, Atsushi Tamura, Sachiko Tsukita Source Type: research