Biomarker correlates of psychotherapy outcomes in borderline personality disorder: A systematic review

Publication date: Available online 9 September 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Ely M. Marceau, Denise Meuldijk, Michelle L. Townsend, Nadia Solowij, Brin F.S. GrenyerAbstractStudies of neurobiological mechanisms in borderline personality disorder (BPD) have increased our understanding of the pathophysiology of its development and course. Less is known about how psychotherapy may influence these neurobiological factors, and also whether biomarkers may predict psychotherapy outcomes. We conducted a systematic review using PRISMA guidelines. Fourteen studies providing data from 467 participants diagnosed with BPD met inclusion criteria to: (a) investigate biomarkers predicting response to psychotherapy for BPD; or (b) examine neurobiological factors altered by psychotherapy. Neuroimaging studies (n = 11) used mostly functional magnetic resonance imaging methods to scope brain regions related to emotion regulation and cognitive control. Three studies examined genetic or neuroendocrine markers. The evidence suggests that psychotherapy alters neural activation and connectivity of regions subserving executive control and emotion regulation. Additionally, hypoactivation in prefrontal and cingulate regions predicted treatment response. Further work in this area may inform personalised treatment approaches in clinical practice for BPD through elucidating neural mechanisms of evidence-based psychotherapy.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

Related Links:

ConclusionsThe grades of BPD-specific symptom severity derived from the distribution of the BSL-23 scores received consistent empirical validation from established assessments for psychopathology. Future studies should expand this validation by including additional instruments e.g., to assess self-esteem, loneliness, connectedness, and quality of life.
Source: Borderline Personality Disorder and Emotion Dysregulation - Category: Psychiatry Source Type: research
In this study, we aim to investigate whether dissociative experiences of BPD patients may be linked to an altered sense of agency and whether self-injurious actions may, through strong sensorial stimulation, constitute a coping strategy for the reduction of the distress associated with these dissociative experiences. A group of 20 BPD patients, of whom 9 presented self-harming behaviors, took part in the study and were compared with an age-matched control group of 20 healthy individuals. Sense of agency was evaluated through the Sensory Attenuation paradigm. In this paradigm, in a comparison with externally generated sensa...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
By nature, humans are wired for connection. We seek out others to share our lives with, with the goal of forming lasting and intimate bonds. So feeling trapped or abandoned in an intimate relationship shouldn’t be a common thing, should it? Actually, these experiences are common for partners who wind up repeating cycles within intimate relationships that they may be unaware of. Feeling trapped or abandoned are commonly seen in the push-pull dynamic found in unhealthy relationships; both styles often represent two sides of the same coin. Engulfment and Abandonment Defined Fear of being engulfed, or trapped, is often i...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Relationships Abandonment Attachment Style Borderline Personality Engulfment Intimacy Self-Esteem Source Type: blogs
Publication date: 15 October 2020Source: Personality and Individual Differences, Volume 165Author(s): Thomas M. Olino, Johanna D. Nielsen, Julia A.C. Case, Elizabeth P. Hayden, Zuzanna Wojcieszak, Rebekah J. Mennies
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
This study examined the presence of posttraumatic stress disorder (PTSD) as a predictor of treatment response to dialectical behavior therapy (DBT) across the primary outcomes of interest within DBT (i.e., borderline personality disorder [BPD] s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Authors: Cichoń L, Janas-Kozik M, Siwiec A, Rybakowski JK Abstract Bipolar disorder (BD) is characterized by pathological changes in mood as well as recurring episodes of mania, hypomania, depression and mixed symptoms. In recent years, the number of BD diagnoses has risen considerably in children and adolescents. Itis believed that anaverage rate of prevalence of bipolar spectrum disorder in the pediatric population is 1.8%, and BD type I - 1.2%, and the prevalence of the disorder increases with the age of patients. Despite the same diagnostic criteria, there are premises that suggest thatthe symptoms of the diso...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
CONCLUSIONS: The usability and satisfaction testing of the B·RIGHT app showed promising findings, which warrant further research in order to validate its effectiveness. PMID: 32438869 [PubMed - as supplied by publisher]
Source: Australasian Psychiatry - Category: Psychiatry Authors: Tags: Australas Psychiatry Source Type: research
Publication date: Available online 19 May 2020Source: Journal of Behavior Therapy and Experimental PsychiatryAuthor(s): Roberta Bortolla, Marco Galli, Pietro Ramella, Federica Sirtori, Raffaele Visintini, Cesare Maffei
Source: Journal of Behavior Therapy and Experimental Psychiatry - Category: Psychiatry Source Type: research
Conclusions: This new two-session short intervention was shown to decrease the emotionally dysregulated behaviors that accompany negative feelings in females with borderline personality disorder.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Previous studies report that individuals diagnosed with borderline personality disorder have been met by negative attitudes from healthcare professionals and their care needs have often been neglected during hospitalizations. When symptoms of  emotional in...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
More News: Borderline Personality Disorder | Brain | Genetics | MRI Scan | Neurology | Neuroscience | Psychotherapy | Study