MnSOD mediates shear stress-promoted tumor cell migration and adhesion.

In this study, we further investigated the mechanisms regulating SS-promoted cell migration and identified the role of MnSOD in the related pathway. We found that SS could enhance tumor cell adhesion to extracellular matrix and endothelial monolayer, and MnSOD also regulated this process. Briefly, SS stimulates the generation of mitochondrial superoxide in tumor cells. MnSOD then converts superoxide into hydrogen peroxide, which activates ERK1/2 to promote tumor cell migration and activates FAK to promote tumor cell adhesion. Combining our previous and present studies, we present experimental evidence on the pro-metastatic effects of hemodynamic SS and reveal the underlying mechanism. Our findings provide new insights into the nature of cancer metastasis and the understanding of tumor cell responses to external stresses and have valuable implications for cancer therapy development. PMID: 30193891 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30193891?dopt=Abstract

Source: Free Radical Biology and Medicine - September 4, 2018 Category: Biology Authors: Ma S, Fu A, Lim S, Chiew GGY, Luo KQ Tags: Free Radic Biol Med Source Type: research