Genotype-guided Warfarin Dosing in Patients with Mechanical Valves: a Randomized Controlled Trial

ConclusionsThe genotype-guided warfarin dosing was safe and might be more efficient with respect to the time to reach a stable dose. Pharmacogenomic testing might be beneficial to identify the patients with the CYP2C9 *1/*3 and the highly sensitive responders, who were high risk subgroup of patients with mechanical heart valves.An appropriately powered study is needed to further confirm the above findings.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research