Anxiety independently contributes to severity of freezing of gait in people with Parkinson's disease - Pimenta M, Moreira D, Nogueira T, Silva C, Pinto EB, Valen ça GT, Almeida LRS.

Freezing of gait is a disabling feature of Parkinson's disease, and it has been shown that nonmotor symptoms, such as anxiety and cognitive impairment, may be involved in the pathophysiology of the phenomenon. However, the association between freezing of g...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

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? Rethinking and Retooling Brain Health and Mental Health from SharpBrains Hoping you enjoy this slidedeck supporting a great discussion held during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7–9th).  Full recordings are available for purchase here. 9–10.30am. How to detect problems early: Examples in Alzheimer’s Disease, Parkinson’s, anxiety and PTSD Dr. Srijan Sen, Professor of Depression and Neurosciences at University of Michigan Jan Samzelius, Co-Founder and Chief Scientist of NeuraMetrix Dr. Tony Chang, Associate at Merck V...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology Alzheimer’s Disease anxiety brain health early detection Parkinsons PTSD Source Type: blogs
AIM: The aim of the present study was to analyze the association of depressive and anxiety symptoms with usual walking and obstacle avoidance in patients with Parkinson's disease. METHODS: Patients were divided into three groups: without depressive...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
CONCLUSIONS: We found that the frequency of RLS in the present patients with PD was higher than that in our previous study of a general population of RLS subjects. Compared to the PD patients without RLS, the present PD patients with RLS suffered from worse sleep quality and QoL, depression, anxiety, and autonomic disturbances, especially those with cardiovascular problems. PMID: 31286703 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Parkinson's disease (PD) is the second most common neurodegenerative disease with an incidence of 1 in 100 people over 50  years of age. Most common symptoms seen in this population are related to the motor system, but with increased awareness of non-motor symptoms (NMS),such as anxiety, depression, stress, fatigue, behavioral changes, sensory and sleep abnormalities are also being reported frequently, including anxi ety, depression, stress, fatigue, behavioral changes, sensory and sleep abnormalities have been reported [1].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Freezing of gait (FOG) is an episodic absence or marked reduction of forward progression of the feet despite the intention to walk [1]. During episodes of freezing, patients feel as if their feet ‘are being glued to the floor’. FOG is common in patients with Parkinson's disease and atypical parkinsonism, and is associated with greater disease severity [2]. Stress, anxiety, a depressive mood and cognitively challenging situations are notorious for provoking or increasing the severity of F OG [3]. Here, we present a patient who clinically presented with a major depressive disorder (MDD) that was accompanied by FO...
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
AbstractPurposePrevious studies in patients with Parkinson ’s disease (PD) and impulse control disorders (ICDs) have produced heterogeneous results regarding striatal dopamine transporter (DaT) binding and activity in the mesocorticolimbic network. Our aim here was to study the relationship between striatal DaT availability and cortical metabolism, as wel l as motor, behavioural and cognitive features of PD patients with ICD.MethodsIn a group of PD patients with ICD (PD-ICD,n = 16) and 16 matched PD patients without ICD (PD-noICD,n = 16), DaT single-photon emission computed tomography (SPE...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Conditions:   Parkinson Disease;   Anxiety Intervention:   Behavioral: Interpretation bias training Sponsor:   King's College London Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 29 June 2019Source: Neuroscience LettersAuthor(s): Camila Medeiros Costa, Gabriella Luciana de Oliveira, Angélica Cristina Sousa Fonseca, Raquel de Carvalho Lana, Janaíne Cunha Polese, Andrei Pereira PernambucoAbstractThe aim of this study was to evaluate salivary cortisol and plasma brain-derived neurotrophic factor (BDNF) in people with PD, to compare them with healthy controls and to associate them with levels of anxiety and depression. For this, 18 people with PD and 17 controls were recruited. The stage of the disease was determined by Hoehn and Yahr Disability Scale (H...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Abstract 5-HT3 receptor antagonists, first introduced to the market in the mid-1980s, are proven efficient agents to counteract chemotherapy-induced emesis. Nonetheless, recent investigations have shed light on unappreciated dimensions of this class of compounds in conditions with an immunoinflammatory component as well as in neurologic and psychiatric disorders. The promising findings from multiple studies have unveiled several beneficial effects of these compounds in multiple sclerosis, stroke, Alzheimer disease, and Parkinson disease. Reports continue to uncover important roles for 5-HT3 receptors in the physio...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rev Source Type: research
Abstract Globally, the human population is exposed to low doses of pesticides due to its extensive use in agriculture. The chronic exposure to pesticides can lead to cancer, depression, anxiety, Parkinson's and Alzheimer's diseases etc. Here, we have made an attempt to use mass spectrometry based metabolomics to investigate the metabolic perturbations induced by the pesticides in the urine and saliva samples of farmers from the Madhya Pradesh State of India. The study was aimed to establish non-invasive matrices like urine and saliva as alternative diagnostic matrices to the occupational exposure studies. Saliva a...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
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