Outcomes After Metabolic Surgery in Asians —a Meta-analysis

ConclusionRYGB results in better weight loss compared to SG in Asians, but the rate of T2DM resolution/improvement and improvement of hypertension appears to be similar. In Asian patients without symptoms of gastro-esophageal reflux disease in whom metabolic surgery is performed mainly for T2DM and metabolic syndrome, SG may be the surgery of choice.
Source: Obesity Surgery - Category: Surgery Source Type: research

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Source: BMJ Comments - Category: General Medicine Source Type: forums
Authors: Fan D, Yang S, Han Y, Zhang R, Yang L Abstract MicroRNAs (miRNAs) are widely known as critical regulators in isoflurane-induced neurotoxicity during the development of brain. Moreover, isoflurane could aggravate cognitive impairment in diabetic rats. The present study was designed to investigate the role and mechanism of miR-140-5p on isoflurane-induced neurotoxicity in diabetic rats. Firstly, a diabetic rat model was established by injection of streptozotocin (STZ) and identified by Morris water maze test. The result indicated that isoflurane treatment exacerbated STZ-induced cognitive impairment, as demo...
Source: Journal of Toxicological Sciences - Category: Toxicology Tags: J Toxicol Sci Source Type: research
Publication date: Available online 19 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Cui Chen, Min Zhou, Yuchen Ge, Xiaobo WangAbstractAging is a biological phenomenon in which the structure and function of organisms declining with the increasing of age. It has become a major risk factor of human diseases, including diabetes, cancers, cardiovascular diseases and neurodegenerative diseases. Silencing information regulator 2 related enzyme 1(sirtuin1, SIRT1) is an NAD+-dependent deacetylase, which has been reported to be involved in the regulation of cellular senescence and aging. The expression of SIRT1...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research
AbstractBackgroundThe proportion of elderly patients undergoing surgery for gastric cancer is increasing. However, limited number of therapeutic outcomes in the elderly has been reported. Here we examined the surgical results based on a nationwide survey of elderly patients who underwent surgery for Stage I gastric cancer.MethodsData from 68,353 Stage I patients who underwent gastrectomy between 2001 and 2007 were retrospectively collected. The accumulated data were reviewed and analyzed by the Japanese Gastric Cancer Association registration committee. We first classified the patients as those aged  ≤ 74&...
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
Publication date: March 2020Source: The Lancet Diabetes &Endocrinology, Volume 8, Issue 3Author(s): Robert Stirrups
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: March 2020Source: The Lancet Diabetes &Endocrinology, Volume 8, Issue 3Author(s):
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: March 2020Source: The Lancet Diabetes &Endocrinology, Volume 8, Issue 3Author(s): Thomas S J Crabtree, Pratik Choudhary, Peter Hammond, Alistair Lumb, Alasdair McLay, Emma G Wilmot
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: March 2020Source: The Lancet Diabetes &Endocrinology, Volume 8, Issue 3Author(s): Emma G Wilmot, Thomas Danne
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Conclusions: Adipose expression of TBX1 is necessary, but not sufficient, to defend body temperature during cold via proper UCP1 expression. Adipose TBX1 expression was also required for proper insulin signaling in subcutaneous adipose as well as maintaining β-adrenergic sensitivity but overexpression of TBX1 was not sufficient to induce adipocyte beiging or prevent diet induced obesity. TBX1 expression is enriched in adipose stem cells in which it has contrasting effects on adipogenesis in mouse versus human cells. Collectively, these data demonstrate the importance of adipose TBX1 in the regulation of beige adipocyt...
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
ConclusionsPPARγ and PPARα synergize to induce robust browning of white fat in vivo, via PPARγ activation in adipose, and PPARα-mediated increase in FGF21.Graphical abstractDual PPARα/γ activation is superior to selective PPARγ activation at inducing browning of white fat in vivo: via PPARγ action in the adipose and a PPARα-mediated action in the liver resulting in increased circulating fibroblast growth factor 21 (FGF21).
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
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