Subclinical myocardial injury during vaso-occlusive crisis in pediatric sickle cell disease

Conclusion: Positive results of troponin I and high levels of galectin-3 in sickle cell children during acute painful crisis were potent indicators for subclinical myocardial injury.What is Known:•The hallmark of sickle cell disease is recurrent episodes of vaso-occlusive crisis which had deleterious effects on many organs.•Cardiac changes in pediatric sickle cell disease whether structural or functional are mainly attributed to chronic anemia and or pulmonary hypertension.What is New:•The observed positive results of cardiac troponin I and high values of galectin-3 in sickle cell children during vaso-occlusive crisis are strong indicator of myocardial ischemia and ongoing cardiac fibrosis respectively.•The observed correlation between biological markers (positive troponin and high galectin-3) could be an indication of subclinical cardiac injury.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research