Lung transplant waiting list rise prompts donation plea

Ageing donors and the challenge of matching organs mean lungs are in short supply.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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I read with great interest the original article by Oishi and colleagues1 and the corresponding letter to the Editor composed by Katz and colleagues. Oishi and colleagues' work is one of the most recent publications from the Toronto lung transplant laboratories and has to be interpreted as such. Having established a protocol, which can be used to safely perfuse human donor lungs ex  vivo, the research group has consequently taken the next step and applies this platform to treat and improve organs.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Thoracic: Lung Transplant: Reply to Letter to the Editor Source Type: research
AbstractIntroductionThere is a strong association between cystic fibrosis and malnutrition, mainly because of the higher energy needs combined with lower intake. There is also a well-established correlation between good nutritional status and better lung function. To date, however, there are no studies examining nutritional status in childhood and adult lung function. To respond to this need, this innovative study explored the long-term correlations between nutritional status in childhood and lung function in adulthood for the same patient population.MethodsA retrospective patient file study was conducted to identify putat...
Source: Lung - Category: Respiratory Medicine Source Type: research
Frailty is common in adults with end-stage lung disease and is associated with death before and after lung transplantation. We aimed to determine whether frailty changes from before to after lung transplant.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We present a CF-patient with disseminated Scedosporium apiospermum infection after lung transplantation. The patient had skin, surgical wound, spinal cord, and brain involvements. She recovered fully after prolonged course of voriconazole treatment.
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
We have applied cutting-edge mass cytometry (MC) technology to serial bronchoalveolar lavage (BAL) cells obtained from lung transplant recipients (LTRs) and have used it to compare the cellular composition of the BAL compartment in patients who remain stable or go on to develop lung allograft dysfunction (LAD), defined here as a drop, from any cause, in the forced expiratory volume in 1 second of 20% from the best post-transplant baseline value.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 17 Source Type: research
We examined the ratio of regulatory T cells (Tregs, which express Foxp3) to T effector cells (Teff) in TBBx as a predictor of outcome.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 16 Source Type: research
Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction, with bronchiolitis obliterans syndrome (BOS) as its most common phenotype. Bronchiectasis (BRECT), hyperinflation and airtrapping are considered the key features of BOS on chest CT. We investigated whether chest CT and key features have prognostic value at BOS diagnosis in patients with established BOS after LTx.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 15 Source Type: research
Chronic Allograft Dysfunction (CLAD) with Bronchiolitis obliterans (BOS) phenotype is a major limitation for long term survival after lung transplantation (LT). Predictive biomarkers for BOS are unavailable. Purpose of our study was to establish a tractable system to evaluate the effects of pre-transplant antibodies to self-antigens (AutoAbs) and to examine specific patterns that correlate with BOS.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 14 Source Type: research
Chronic lung allograft dysfunction (CLAD) is a clinical/functional diagnosis that cannot be defined by histology in transbronchial biopsies (TBBs). Moreover, understanding the biology of CLAD is crucial for prevention and potential treatment. We studied gene expression associated with CLAD in TBBs, but also studied mucosal biopsies from the third bronchial bifurcation (3BMBs).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 13 Source Type: research
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