Elevated allostatic load index is associated with working memory deficits in first-episode psychosis

Cognitive impairment represents one of core characteristics of schizophrenia psychopathology. Chronic stress might impact cognition via various mechanisms (Marin et al., 2011). According to the allostatic load (AL) concept, processes that are activated in response to stress are adaptive in a short-term perspective and enable to maintain homeostasis (McEwen and Wingfield, 2003). These processes have been termed ‘allostasis’. The AL refers to detrimental effects of chronic stress exposure that appear due to over-activation of allostatic mechanisms.

Source: Schizophrenia Research - September 7, 2018 Category: Psychiatry Authors: B łażej Misiak, Kamila Kotowicz, Olga Loska, Filip Stramecki, Jan Aleksander Beszłej, Jerzy Samochowiec, Agnieszka Samochowiec, Marcin Jabłoński, Piotr Podwalski, Katarzyna Waszczuk, Michał Wroński, Anna Michalczyk, Leszek Sagan, Patryk Piotrowski Tags: Letter to the Editor Source Type: research