Depression Treatment: Where We Are Missing the Mark

Depression affects 450 million people worldwide and 15 million adults in the United States (U.S.) alone. Suicide is the 10th leading cause of death in the United States, claiming over 40,000 lives every year. We see these heartbreaking stories making headlines too often, and there are tens of thousands more we do not know about. The scariest part? There is no end in sight. Antidepressants are one of the three most commonly used therapeutic drug classes in the United States. Approximately 1 in 9 Americans of all ages reported taking at least one antidepressant medication — a number that was less than 1 in 50 just three decades ago. The recent suicides of Kate Spade and Anthony Bourdain highlighted the growing need for a comprehensive solution for depression rates in the United States. In response to the suicides, many turned to the FDA to develop new drugs. So, why aren’t suicide rates dropping? The reality is up to one third of patients suffering from depression do not respond to or cannot tolerate antidepressant medication. Today, there are a number of other treatments that have been proven to be effective in helping those with treatment-resistant depression achieve remission. These treatments can work in combination with each other and psychotherapy. Deep transcranial magnetic stimulation (Deep TMS), the “helmet that treats depression”, is a non-invasive neurostimulation therapy that uses magnetic fields to stimulate nerve cells in the brain to im...
Source: Psych Central - Category: Psychiatry Authors: Tags: Antidepressants Bipolar Depression Medications Mood Stabilizers Neuroscience Suicide Treatment Deep brain stimulation Deep transcranial magnetic stimulation Depression Treatment Electroconvulsive Therapy Major Depressive Disorder Source Type: news

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Authors: Barton BB, Segger F, Fischer K, Obermeier M, Musil R Abstract Introduction: Antipsychotic-induced weight-gain (AIWG) is a very important, yet often neglected side-effect in the treatment with first and second generation antipsychotics. AIWG can increase the risk of developing metabolic syndrome, diabetes and cardiovascular disease. Meta-analyses mostly concentrate on AIWG in schizophrenic and bipolar patients, even though antipsychotics are prescribed off-label across many other diagnostic groups (e.g. anxiety disorders, depression, autistic disorder).Areas covered: Pub Med and Web of Science were systemat...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
In this study, we discovered that chronic alcohol treatment increased editing of RNA of 5-HT2CR via up-regulating the expression of ADAR2, consequently reducing the release of ATP from astrocytes induced by 5-HT2CR agonist, MK212. Moreover, SSRI antidepressant fluoxetine decreased the expression of ADAR2 through the transactivation of EGFR/PI3K/AKT/cFos signalling pathway. The increased release of astroglial ATP by MK212 which was suppressed by chronic alcohol consumption, and reduction in ADAR2 activity eliminated the RNA editing of 5-HT2CR increased by alcohol in vitro and recovered the release of ATP from astrocytes ind...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
This article includes references to self-injury, intravenous drug use and disordered eating.* One in five US high school students have reported being bullied. Approximately 160,000 teenagers have skipped school as a preventative measure. I encountered bullies for the first time in second grade, in the midst of such an innocent time of my youth. I dreaded entering my elementary school classroom, as I was well aware of what my presence would entail. I endured both verbal and physical harassment from my fellow peers for nearly a decade. I was passive, inevitably leading to the acceptance of my “fate,” in addition ...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Anorexia Bullying Depression Eating Disorders Personal Stories Substance Abuse Addiction Recovery Anorexia Nervosa Drug Use heroin Self Harm Self Injury Source Type: news
The risk of developing bipolar disorder was increased in women with PCOS, possibly because of shared inflammatory pathways, a study has found; metformin may have a protective effect.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Ob/Gyn & Women ' s Health News Source Type: news
Authors: Augstburger E, Héron E, Abanou A, Habas C, Baudouin C, Labbé A Abstract Ischemic optic neuropathies are among the leading causes of severe visual acuity loss in people over 50 years of age. They constitute a set of various entities that are clinically, etiologically and therapeutically different. Anatomically, it is necessary to distinguish anterior and posterior forms. From an etiological point of view, the diagnosis of the arteritic form due to giant cell arteritis requires emergent management to prevent blindness and even death in the absence of prompt corticosteroid treatment. When this d...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC09904B, CommunicationAnthony J. Campanella, Benjamin A. Trump, Eric Gosselin, Eric D Bloch, Craig M Brown Metal-organic frameworks featuring open metal coordination sites have been widely studied for the separation of gas mixtures. For CO2/N2 separations, these materials have shown considerable promise. Herein, we report the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
RESUMO Os pacientes com s índrome do desconforto respiratório agudo requerem estratégias ventilatórias que demonstraram ser importantes na redução da mortalidade em curto prazo, como ventilação protetora e ventilação em posição prona. No entanto, os pacientes que sobrevivem têm permanência prolongada, tanto na unidade de terapia intensiva como no hospital, e experimentam redução na satisfação global com a vida (independência, aceitação e perspectiva positiva), na saúde menta...
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
BACKGROUND: Suicide is a leading cause of death among adolescents in North America. Youth who present to the Emergency Department (ED) with acute suicidality are at increased risk for eventual death by suicide, thereby presenting an opportunity for seconda...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Adolescent-onset depression and anxiety represent a substantial, and growing, health-care burden. Unfortunately, traditional treatments for depression and anxiety that are effective in adults have small success rates in paediatric populations. 1 Theref...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This study utilized ecological momentary assessment (EMA) to sharpen understanding of whether non-suicidal self-injury (NSSI) thought intensity and duration impacts NSSI behavior and potential alternative behaviors to NSSI. Self-injuring adolescents and yo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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