Targeted Imaging of Renal Fibrosis Using Antibody-Conjugated Gold Nanoparticles in Renal Artery Stenosis

Conclusion Gold nanoparticles conjugated to an anti-collagen-I antibody are able to visualize kidney fibrosis in vitro and in situ and may be useful for nondestructive quantification of tissue fibrosis.
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research

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Siemens (NYSE:SI) Healthineers said today that it won FDA clearance for its Cios Spin mobile C-arm device for intraoperative 3D imaging. The newly cleared Cios Spin produces 3D computed tomography-like imaging for orthopedic, trauma and spinal surgery that Siemens claims can reduce the rate of revisions and need for post-operative CT. The Cios Spin supports both 2D and 3D imaging and can be used for a variety of procedures, including vascular imaging, Siemens said. The system also features NaviLink 3D digital navigation and flat panel detector technology and other software packages. “Siemens Healthineers is...
Source: Mass Device - Category: Medical Devices Authors: Tags: 510(k) Food & Drug Administration (FDA) Imaging Regulatory/Compliance Siemens Healthineers Source Type: news
Conclusion: The administration of both IV and intra-arterial contrast is associated with a risk of AKI. Multifactorial AKI was associated with worse outcomes, while CIN was associated with better outcomes.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
Publication date: Available online 5 October 2018Source: Journal of Vascular and Interventional RadiologyAuthor(s): Wenhui Zhou, Sanna E. Herwald, Raul N. Uppot, Ronald S. ArellanoAbstractPurposeTo assess safety and renal-function outcomes after microwave (MW) ablation of localized stage T1 renal cell carcinoma (RCC).Materials and MethodsA retrospective review was conducted of 38 patients (28 men; mean age, 69 y; range, 51–88 y) who underwent computed tomography (CT)–guided MW ablation for stage T1N0M0 RCC. Baseline and follow-up renal function surrogates including creatinine level and estimated glomerular filt...
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Authors: Higuchi R, Tobaru T, Hagiya K, Saji M, Takamisawa I, Shimizu J, Iguchi N, Takanashi S, Takayama M Abstract The therapeutic role of transcatheter aortic valve implantation (TAVI) in high surgical risk or inoperable cases has been established. Most of the candidates for TAVI are elderly and have multiple comorbidities including chronic kidney disease. However, contrast-enhanced computed tomography and coronary angiography, both of which require iodine contrast media, are essential for pre-procedural planning. In addition, TAVI could have adverse effects on kidney function including contrast media-induced nep...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
AbstractRenal osteodystrophy (ROD) is a metabolic skeletal pathology that frequently affects the orofacial region and presents with characteristic radiological manifestations. This paper reports a case of ROD causing diffused orofacial bone alterations in a female patient with end-stage chronic kidney disease. The radiological features on panoramic, posteroanterior and lateral skull and computed tomography radiographs are described for this case. Previous reports in the literature are reviewed and discussed with a focus on radiological characteristics and differential diagnoses.
Source: Oral Radiology - Category: Radiology Source Type: research
Conclusions- The observed changes in lymph flow suggest that the lymphatics may influence long-term regulation of tissue fluid balance during salt accumulation by contributing to fluid homeostasis in skin and muscle. Our studies identify lymph clearance as a potential disease-modifying factor that might be targeted in conditions characterized by salt accumulation like chronic kidney disease and salt-sensitive hypertension. PMID: 30354256 [PubMed - in process]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
We report a case of PLSVC in a patient with chronic kidney disease which was identified following a difficult catheterization into the right internal jugular vein (IJV). The catheterization was attempted through the left IJV and the position of which could not be confirmed with check radiograph and two-dimensional echo. PLSVC was suspected in the computed tomography angiography and was confirmed following digital subtraction angiography.
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Authors: Krishnasamy R, Hawley CM, Johnson DW Abstract INTRODUCTION: Bone disorders in chronic kidney disease (CKD) are associated with heightened risks of fractures, vascular calcification, poor quality of life and mortality compared to the general population. However, diagnosis and management of these disorders in CKD are complex and appreciably limited by current diagnostic modalities. Areas covered: Bone histomorphometry remains the gold standard for diagnosis but is not widely utilised and lacks feasibility as a monitoring tool. In practice, non-invasive imaging and biochemical markers are preferred to guide t...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
We report a case of a TAVI in an 80-year-old patient with severe AS and significant chronic kidney disease (CKD), which was carried out without the use of contrast and with minimal procedural hypotension.Pre-procedural imaging was carried out using 3D trans-esophageal echocardiography (TEE) rather than computed tomography (CT) to avoid contrast administration. The Lotus valve (Boston Scientific, Marlborough, MA, USA) was chosen due to a number of design features which minimize both the need for contrast injection and procedural hypotension during valve positioning and deployment. The procedure was carried out successfully ...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Conclusions: The presence of CKD did not have a significant impact on the development of coronary atherosclerosis, but affected the progression of coronary calcification more markedly from the stage of moderate CKD in nondiabetics. However, in diabetics, the deterioration of renal function was significantly associated with the development of coronary atherosclerosis and calcification from the stage of mild CKD.Cardiorenal Med 2018;8:228 –236
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research
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