Targeted Imaging of Renal Fibrosis Using Antibody-Conjugated Gold Nanoparticles in Renal Artery Stenosis

Conclusion Gold nanoparticles conjugated to an anti-collagen-I antibody are able to visualize kidney fibrosis in vitro and in situ and may be useful for nondestructive quantification of tissue fibrosis.
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research

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This report describes a massive pleural effusion that led to the discovery of subclavian artery rupture causing hemodynamic shock. Hemodynamic instability in this patient was caused by hypovolemic and obstructive shock, with a pleural perfusion caused by subclavian artery rupture. Monitoring via transesophageal echocardiography during the procedure enabled early discovery of the massive pleural effusion. Subsequent covered stent implantation stabilized the subclavian artery rupture, and the patient became hemodynamically stable. As subclavian artery rupture can occur during trans-subclavian TAVI, the presence of calcificat...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Postcontrast acute kidney injury (AKI) occurs more frequently in patients with lower estimated glomerular filtration rate. We hypothesized that postcontrast AKI in chronic kidney disease (CKD) patients with distinct risk factors might be associated with accelerated renal progression. We undertook this retrospective cohort study to develop and validate a risk scoring model for predicting renal progression. In a development dataset, 18,278 contrast-enhanced CT scans were performed in 9097 patients with CKD (estimated glomerular filtration rate [eGFR] 
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
This is the first reported case of necrotizing nasal and sinus herpes infection with orbital involvement. A 94-year-old male with a past medical history of hypertension, congestive heart failure, and chronic kidney disease presented with necrotic nasal cellulitis and a red left eye with blurry vision. Onset was 2 weeks prior with an upper lip fever blister. He was admitted to medicine and started on antimicrobials. Maxillofacial computed tomography scan revealed pansinusitis with involvement of bilateral medial orbital walls. Initial nasal biopsy was negative. Repeat biopsy was positive for herpes simplex virus 1. His nose...
Source: Ophthalmic Plastic and Reconstructive Surgery - Category: Opthalmology Tags: Case Reports Source Type: research
Abstract BACKGROUND: The relationship between oral activated charcoal (OAC) and hyperphosphatemia and vascular calcification is not completely clear. We observed and recorded the effects of OAC on hyperphosphatemia and vascular calcification in stage 3-4 chronic kidney disease (CKD). METHODS: In a randomized controlled study, we included 97 patients with stage 3-4 CKD. In the first phase of the experiment, the patients were randomly divided into the OAC group and placebo group. The endpoint of this phase was the development of hyperphosphatemia. The patients with hyperphosphatemia were selected into the secon...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
ConclusionsMönckeberg medial calcinosis is an incidental finding on panoramic or CBCT imaging. Clinically and radiographically, its importance for the clinician is its strong association with diabetes and chronic kidney disease. The significance of Mönckeberg sclerosis of the infraorbital arteries is unknown. Radiologists and clinicians should be aware of this entity and the importance of documentation of any findings.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
CONCLUSIONS: Our proteomics approach identified plasma KIM-1 as a risk marker for cardiovascular mortality and coronary artery calcification in three independent ESRD-cohorts. The improved risk prediction for cardiovascular mortality by plasma proteomics merit further studies. PMID: 30499038 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
CONCLUSIONSDespite no measurable disease remaining on preinfusion imaging, CAR-T cell expansion was observed in 7 of 8 pts in this setting, similar to the expansion in adults with active r/r DLBCL. Five of the 8 pts remained on study and were progression free> 12 months after infusion, which is higher than would be estimated with bridging chemotherapy alone. These data provide preliminary evidence that CAR-T cells provide clinical benefit in pts with r/r DLBCL who achieve CR with subsequent therapies and for design of CAR-T cell trials as consolidative therapy.DisclosuresBishop: United Healthcare: Employment; Seattle Ge...
Source: Blood - Category: Hematology Authors: Tags: 626. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Prospective Clinical Trials: Poster II Source Type: research
Introduction: CMML is a myeloid neoplasm hallmarked by cytopenias and a peripheral monocytosis. Although uniformly fatal, many patients (pts) are diagnosed incidentally and are monitored without treatment. Therapy is implemented when symptomatic cytopenias, splenomegaly, or bone marrow progression occur. Higher white blood cell count (WBC) and absolute monocyte count (AMC) are associated with inferior OS, however, they are currently not an indication for treatment. Case reports have demonstrated a putative link between CMML monocytes and end organ damage (EOD), which has not been systematically explored. We hypothesize tha...
Source: Blood - Category: Hematology Authors: Tags: 637. Myelodysplastic Syndromes-Clinical Studies: Poster II Source Type: research
Siemens (NYSE:SI) Healthineers said today that it won FDA clearance for its Cios Spin mobile C-arm device for intraoperative 3D imaging. The newly cleared Cios Spin produces 3D computed tomography-like imaging for orthopedic, trauma and spinal surgery that Siemens claims can reduce the rate of revisions and need for post-operative CT. The Cios Spin supports both 2D and 3D imaging and can be used for a variety of procedures, including vascular imaging, Siemens said. The system also features NaviLink 3D digital navigation and flat panel detector technology and other software packages. “Siemens Healthineers is...
Source: Mass Device - Category: Medical Devices Authors: Tags: 510(k) Food & Drug Administration (FDA) Imaging Regulatory/Compliance Siemens Healthineers Source Type: news
Conclusion: The administration of both IV and intra-arterial contrast is associated with a risk of AKI. Multifactorial AKI was associated with worse outcomes, while CIN was associated with better outcomes.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
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